Differential integrin expression in thyroid and laryngeal carcinomas

Maria Teresa Carlevato; Livio Trusolino; Guido Serini; Guido Valente; Fabio Orlandi; Alberto Angeli; Giorgio Cortesina; Pier Carlo Marchisio

Differential integrin expression in thyroid and laryngeal carcinomas

Maria Teresa Carlevato, Livio Trusolino, Guido Serini, Guido Valente, Fabio Orlandi, Alberto Angeli, Giorgio Cortesina, Pier Carlo Marchisio

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.

Lingua originale	Inglese
pagine (da-a)	2379-2384
Numero di pagine	6
Rivista	Anticancer Research
Volume	16
Numero di pubblicazione	4 C
Stato di pubblicazione	Pubblicato - lug 1996
Pubblicato esternamente	Sì

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title = "Differential integrin expression in thyroid and laryngeal carcinomas",

abstract = "Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.",

keywords = "Adhesion molecules, Integrins, Laryngeal cancer, Thyroid cancer",

author = "Carlevato, {Maria Teresa} and Livio Trusolino and Guido Serini and Guido Valente and Fabio Orlandi and Alberto Angeli and Giorgio Cortesina and Marchisio, {Pier Carlo}",

year = "1996",

month = jul,

language = "English",

volume = "16",

pages = "2379--2384",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Differential integrin expression in thyroid and laryngeal carcinomas

AU - Carlevato, Maria Teresa

AU - Trusolino, Livio

AU - Serini, Guido

AU - Valente, Guido

AU - Orlandi, Fabio

AU - Angeli, Alberto

AU - Cortesina, Giorgio

AU - Marchisio, Pier Carlo

PY - 1996/7

Y1 - 1996/7

N2 - Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.

AB - Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.

KW - Adhesion molecules

KW - Integrins

KW - Laryngeal cancer

KW - Thyroid cancer

UR - http://www.scopus.com/inward/record.url?scp=0029789487&partnerID=8YFLogxK

M3 - Article

SN - 0250-7005

VL - 16

SP - 2379

EP - 2384

JO - Anticancer Research

JF - Anticancer Research

IS - 4 C

ER -

Differential integrin expression in thyroid and laryngeal carcinomas

Abstract

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