TY - JOUR
T1 - Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinoma
AU - BELLONE, G
AU - CARBONE, A
AU - TIBAUDI, D
AU - MAURI, F
AU - FERRERO, I
AU - SMIRNE, Carlo
AU - SUMAN, F
AU - RIVETTI, C
AU - MIGLIARETTI, G
AU - CAMANDONA, M
AU - PALESTRO, G
AU - EMANUELLI, G
AU - RODECK, U.
N1 - Funding Information:
This work was supported in part by a grant from Regione Piemonte to G.B. I.F. is the recipient of a Regione Piemonte award.
PY - 2001
Y1 - 2001
N2 - Transforming growth factor (TGF)-beta is a protein family which affects multiple cellular functions including survival, proliferation, differentiation and adhesion. Among the three known isoforms, TGF-beta1 is commonly overexpressed in solid malignancies. Recent studies in knock-out mice demonstrated non-redundant roles of different TGF-beta isoforms in development. The present study was performed to assess tumour-associated expression of the three TGF-beta isoforms in colon carcinoma. We report that colon carcinoma progression is associated with gradual and significant increases in expression of TGF-beta1 and TGF-beta2 mRNA and proteins. By contrast, TGF-beta3 expression was detected in normal colonic mucosa and, at slightly higher levels, in tumour tissues. In addition, plasma levels of both TGF-beta1 and TGF-beta2 were significantly higher in cancer patients when compared with unaffected individuals. Taken together, our results indicate distinct expression patterns of the three TGF-beta isoforms in colon carcinoma cells and possible systemic effects of TGF-beta1 and TGF-beta2 in tumour patients.
AB - Transforming growth factor (TGF)-beta is a protein family which affects multiple cellular functions including survival, proliferation, differentiation and adhesion. Among the three known isoforms, TGF-beta1 is commonly overexpressed in solid malignancies. Recent studies in knock-out mice demonstrated non-redundant roles of different TGF-beta isoforms in development. The present study was performed to assess tumour-associated expression of the three TGF-beta isoforms in colon carcinoma. We report that colon carcinoma progression is associated with gradual and significant increases in expression of TGF-beta1 and TGF-beta2 mRNA and proteins. By contrast, TGF-beta3 expression was detected in normal colonic mucosa and, at slightly higher levels, in tumour tissues. In addition, plasma levels of both TGF-beta1 and TGF-beta2 were significantly higher in cancer patients when compared with unaffected individuals. Taken together, our results indicate distinct expression patterns of the three TGF-beta isoforms in colon carcinoma cells and possible systemic effects of TGF-beta1 and TGF-beta2 in tumour patients.
UR - https://iris.uniupo.it/handle/11579/9188
M3 - Article
SN - 0959-8049
VL - 37
SP - 224
EP - 233
JO - European Journal of Cancer
JF - European Journal of Cancer
ER -
