Differential analysis of 2-D maps by pixel-based approaches

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Abstract

Two approaches to the analysis of 2-D maps are available: the first one involves a step of spot detection on each gel image; the second one is based instead on the direct differential analysis of 2-D map images, following a pixel-based procedure. Both approaches strongly depend on the proper alignment of the gel images, but the pixel-based approach allows to solve important drawbacks of the spot-volume procedure, i.e., the problem of missing data and of overlapping spots. However, this approach is quite computationally intensive and requires the use of algorithms able to separate the information (i.e., spot-related information) from the background. Here, the most recent pixel-based approaches are described.

Lingua originaleInglese
Titolo della pubblicazione ospiteMethods in Molecular Biology
EditoreHumana Press Inc.
Pagine299-327
Numero di pagine29
DOI
Stato di pubblicazionePubblicato - 2016

Serie di pubblicazioni

NomeMethods in Molecular Biology
Volume1384
ISSN (stampa)1064-3745

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