@inbook{609f74af87814badafd09ef9e99d7ce7,
title = "Differential analysis of 2-D maps by pixel-based approaches",
abstract = "Two approaches to the analysis of 2-D maps are available: the first one involves a step of spot detection on each gel image; the second one is based instead on the direct differential analysis of 2-D map images, following a pixel-based procedure. Both approaches strongly depend on the proper alignment of the gel images, but the pixel-based approach allows to solve important drawbacks of the spot-volume procedure, i.e., the problem of missing data and of overlapping spots. However, this approach is quite computationally intensive and requires the use of algorithms able to separate the information (i.e., spot-related information) from the background. Here, the most recent pixel-based approaches are described.",
keywords = "Fuzzy logic, Gel-electrophoresis, Pixel-based approach, Three-way PCA",
author = "Emilio Marengo and Elisa Robotti and Fabio Quasso",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016.",
year = "2016",
doi = "10.1007/978-1-4939-3255-9_17",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "299--327",
booktitle = "Methods in Molecular Biology",
}