Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

E. K. Aglago; N. Murphy; I. Huybrechts; G. Nicolas; C. Casagrande; V. Fedirko; E. Weiderpass; J. A. Rothwell; C. C. Dahm; A. Olsen; A. Tjonneland; R. Kaaks; V. Katzke; M. B. Schulze; G. Masala; C. Agnoli; S. Panico; R. Tumino; Carlotta SACERDOTE; B. H. Bueno-de-Mesquita; J. W. G. Derksen; G. Skeie; I. T. Gram; M. Brustad; P. Jakszyn; Sanchez M. -J.; P. Amiano; J. M. Huerta; U. Ericson; M. Wennberg; A. Perez-Cornago; A. K. Heath; M. Jenab; V. Chajes; M. J. Gunter

doi:10.1002/ijc.33615

Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

E. K. Aglago, N. Murphy, I. Huybrechts, G. Nicolas, C. Casagrande, V. Fedirko, E. Weiderpass, J. A. Rothwell, C. C. Dahm, A. Olsen, A. Tjonneland, R. Kaaks, V. Katzke, M. B. Schulze, G. Masala, C. Agnoli, S. Panico, R. Tumino, Carlotta SACERDOTE, B. H. Bueno-de-MesquitaJ. W. G. Derksen, G. Skeie, I. T. Gram, M. Brustad, P. Jakszyn, Sanchez M. -J., P. Amiano, J. M. Huerta, U. Ericson, M. Wennberg, A. Perez-Cornago, A. K. Heath, M. Jenab, V. Chajes, M. J. Gunter

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HRQ5vsQ1 = 0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vsQ1 = 0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vsQ1 = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, ORQ4vsQ1 = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vsQ1 = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR1-SD = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD = 1.04, 95%CI:0.95-1.15, Pheterogeneity = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.

Lingua originale	Inglese
pagine (da-a)	865-882
Numero di pagine	18
Rivista	International Journal of Cancer
Volume	149
Numero di pubblicazione	4
DOI	https://doi.org/10.1002/ijc.33615
Stato di pubblicazione	Pubblicato - 2021

Keywords

biomarker
colorectal cancer
dietary intake
fatty acids

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10.1002/ijc.33615

https://hdl.handle.net/11579/198772

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Aglago, E. K., Murphy, N., Huybrechts, I., Nicolas, G., Casagrande, C., Fedirko, V., Weiderpass, E., Rothwell, J. A., Dahm, C. C., Olsen, A., Tjonneland, A., Kaaks, R., Katzke, V., Schulze, M. B., Masala, G., Agnoli, C., Panico, S., Tumino, R., SACERDOTE, C., ... Gunter, M. J. (2021). Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. International Journal of Cancer, 149(4), 865-882. https://doi.org/10.1002/ijc.33615

@article{0e79a4e3118d41528242e04582aaff92,

title = "Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort",

abstract = "Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HRQ5vsQ1 = 0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vsQ1 = 0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vsQ1 = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, ORQ4vsQ1 = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vsQ1 = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR1-SD = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD = 1.04, 95%CI:0.95-1.15, Pheterogeneity = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.",

keywords = "biomarker, colorectal cancer, dietary intake, fatty acids, biomarker, colorectal cancer, dietary intake, fatty acids",

author = "Aglago, {E. K.} and N. Murphy and I. Huybrechts and G. Nicolas and C. Casagrande and V. Fedirko and E. Weiderpass and Rothwell, {J. A.} and Dahm, {C. C.} and A. Olsen and A. Tjonneland and R. Kaaks and V. Katzke and Schulze, {M. B.} and G. Masala and C. Agnoli and S. Panico and R. Tumino and Carlotta SACERDOTE and Bueno-de-Mesquita, {B. H.} and Derksen, {J. W. G.} and G. Skeie and Gram, {I. T.} and M. Brustad and P. Jakszyn and -J., {Sanchez M.} and P. Amiano and Huerta, {J. M.} and U. Ericson and M. Wennberg and A. Perez-Cornago and Heath, {A. K.} and M. Jenab and V. Chajes and Gunter, {M. J.}",

year = "2021",

doi = "10.1002/ijc.33615",

language = "English",

volume = "149",

pages = "865--882",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

Aglago, EK, Murphy, N, Huybrechts, I, Nicolas, G, Casagrande, C, Fedirko, V, Weiderpass, E, Rothwell, JA, Dahm, CC, Olsen, A, Tjonneland, A, Kaaks, R, Katzke, V, Schulze, MB, Masala, G, Agnoli, C, Panico, S, Tumino, R, SACERDOTE, C, Bueno-de-Mesquita, BH, Derksen, JWG, Skeie, G, Gram, IT, Brustad, M, Jakszyn, P, -J., SM, Amiano, P, Huerta, JM, Ericson, U, Wennberg, M, Perez-Cornago, A, Heath, AK, Jenab, M, Chajes, V & Gunter, MJ 2021, 'Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort', International Journal of Cancer, vol. 149, n. 4, pagg. 865-882. https://doi.org/10.1002/ijc.33615

Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. / Aglago, E. K.; Murphy, N.; Huybrechts, I. et al.
In: International Journal of Cancer, Vol. 149, N. 4, 2021, pag. 865-882.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

AU - Aglago, E. K.

AU - Murphy, N.

AU - Huybrechts, I.

AU - Nicolas, G.

AU - Casagrande, C.

AU - Fedirko, V.

AU - Weiderpass, E.

AU - Rothwell, J. A.

AU - Dahm, C. C.

AU - Olsen, A.

AU - Tjonneland, A.

AU - Kaaks, R.

AU - Katzke, V.

AU - Schulze, M. B.

AU - Masala, G.

AU - Agnoli, C.

AU - Panico, S.

AU - Tumino, R.

AU - SACERDOTE, Carlotta

AU - Bueno-de-Mesquita, B. H.

AU - Derksen, J. W. G.

AU - Skeie, G.

AU - Gram, I. T.

AU - Brustad, M.

AU - Jakszyn, P.

AU - -J., Sanchez M.

AU - Amiano, P.

AU - Huerta, J. M.

AU - Ericson, U.

AU - Wennberg, M.

AU - Perez-Cornago, A.

AU - Heath, A. K.

AU - Jenab, M.

AU - Chajes, V.

AU - Gunter, M. J.

PY - 2021

Y1 - 2021

N2 - Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HRQ5vsQ1 = 0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vsQ1 = 0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vsQ1 = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, ORQ4vsQ1 = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vsQ1 = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR1-SD = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD = 1.04, 95%CI:0.95-1.15, Pheterogeneity = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.

AB - Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HRQ5vsQ1 = 0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vsQ1 = 0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vsQ1 = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, ORQ4vsQ1 = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vsQ1 = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR1-SD = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD = 1.04, 95%CI:0.95-1.15, Pheterogeneity = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.

KW - biomarker

KW - colorectal cancer

KW - dietary intake

KW - fatty acids

KW - biomarker

KW - colorectal cancer

KW - dietary intake

KW - fatty acids

UR - https://iris.uniupo.it/handle/11579/198772

U2 - 10.1002/ijc.33615

DO - 10.1002/ijc.33615

M3 - Article

SN - 0020-7136

VL - 149

SP - 865

EP - 882

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 4

ER -

Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Abstract

Keywords

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