TY - JOUR
T1 - Dietary glycemic load and index and risk of coronary heart disease in a large Italian cohort
T2 - The EPICOR study
AU - Sieri, Sabina
AU - Krogh, Vittorio
AU - Berrino, Franco
AU - Evangelista, Alberto
AU - Agnoli, Claudia
AU - Brighenti, Furio
AU - Pellegrini, Nicoletta
AU - Palli, Domenico
AU - Masala, Giovanna
AU - Sacerdote, Carlotta
AU - Veglia, Fabrizio
AU - Tumino, Rosario
AU - Frasca, Graziella
AU - Grioni, Sara
AU - Pala, Valeria
AU - Mattiello, Amalia
AU - Chiodini, Paolo
AU - Panico, Salvatore
PY - 2010/4/12
Y1 - 2010/4/12
N2 - Background: Dietary glycemic load (GL) and glycemic index (GI) in relation to cardiovascular disease have been investigated in a few prospective studies with inconsistent results, particularly in men. The present EPICOR study investigated the association of GI and GL with coronary heart disease (CHD) in a large and heterogeneous cohort of Italian men and women originally recruited to the European Prospective Investigation into Cancer and Nutrition study. Methods: We studied 47 749 volunteers (15 171 men and 32 578 women) who completed a dietary questionnaire. Multivariate Cox proportional hazards modeling estimated adjusted relative risks (RRs) of CHD and 95% confidence intervals (CIs). Results: During a median of 7.9 years of follow-up, 463 CHD cases (158 women and 305 men) were identified. Women in the highest carbohydrate intake quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.00; 95% CI,1.16-3.43), with no association found in men (P=.04 for interaction). Increasing carbohydrate intake from high-GI foods was also significantly associated with greater risk of CHDin women (RR, 1.68; 95% CI, 1.02-2.75), whereas increasing the intake of low-GI carbohydrates was not. Women in the highest GL quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.24; 95% CI, 1.26-3.98), with no significant association in men (P=.03 for interaction). Conclusion: In this Italian cohort, high dietary GL and carbohydrate intake from high-GI foods increase the over-all risk of CHD in women but not men.
AB - Background: Dietary glycemic load (GL) and glycemic index (GI) in relation to cardiovascular disease have been investigated in a few prospective studies with inconsistent results, particularly in men. The present EPICOR study investigated the association of GI and GL with coronary heart disease (CHD) in a large and heterogeneous cohort of Italian men and women originally recruited to the European Prospective Investigation into Cancer and Nutrition study. Methods: We studied 47 749 volunteers (15 171 men and 32 578 women) who completed a dietary questionnaire. Multivariate Cox proportional hazards modeling estimated adjusted relative risks (RRs) of CHD and 95% confidence intervals (CIs). Results: During a median of 7.9 years of follow-up, 463 CHD cases (158 women and 305 men) were identified. Women in the highest carbohydrate intake quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.00; 95% CI,1.16-3.43), with no association found in men (P=.04 for interaction). Increasing carbohydrate intake from high-GI foods was also significantly associated with greater risk of CHDin women (RR, 1.68; 95% CI, 1.02-2.75), whereas increasing the intake of low-GI carbohydrates was not. Women in the highest GL quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.24; 95% CI, 1.26-3.98), with no significant association in men (P=.03 for interaction). Conclusion: In this Italian cohort, high dietary GL and carbohydrate intake from high-GI foods increase the over-all risk of CHD in women but not men.
UR - http://www.scopus.com/inward/record.url?scp=77950988334&partnerID=8YFLogxK
U2 - 10.1001/archinternmed.2010.15
DO - 10.1001/archinternmed.2010.15
M3 - Article
SN - 0003-9926
VL - 170
SP - 640
EP - 647
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 7
ER -
