Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort

Anne E. Cust; Nadia Slimani; Rudolf Kaaks; Marit Van Bakel; Carine Biessy; Pietro Ferrari; Martine Laville; Anne Tjønneland; Anja Olsen; Kim Overvad; Martin Lajous; Francoise Clavel-Chapelon; Marie Christine Boutron-Ruault; Jakob Linseisen; Sabine Rohrmann; Ute Nöthlings; Heiner Boeing; Domenico Palli; Sabina Sieri; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; Guri Skeie; Dagrun Engeset; Inger Torhild Gram; J. Ramón Quirós; Paula Jakszyn; María José Sánchez; Nerea Larrañaga; Carmen Navarro; Eva Ardanaz; Elisabet Wirfält; Göran Berglund; Eva Lundin; Göran Hallmans; H. Bas Bueno-De-Mesquita; Huaidong Du; Petra H.M. Peeters; Sheila Bingham; Kay Tee Khaw; Naomi E. Allen; Timothy J. Key; Mazda Jenab; Elio Riboli

doi:10.1093/aje/kwm161

Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort

Anne E. Cust, Nadia Slimani, Rudolf Kaaks, Marit Van Bakel, Carine Biessy, Pietro Ferrari, Martine Laville, Anne Tjønneland, Anja Olsen, Kim Overvad, Martin Lajous, Francoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Jakob Linseisen, Sabine Rohrmann, Ute Nöthlings, Heiner Boeing, Domenico Palli, Sabina Sieri, Salvatore PanicoRosario Tumino, Carlotta Sacerdote, Guri Skeie, Dagrun Engeset, Inger Torhild Gram, J. Ramón Quirós, Paula Jakszyn, María José Sánchez, Nerea Larrañaga, Carmen Navarro, Eva Ardanaz, Elisabet Wirfält, Göran Berglund, Eva Lundin, Göran Hallmans, H. Bas Bueno-De-Mesquita, Huaidong Du, Petra H.M. Peeters, Sheila Bingham, Kay Tee Khaw, Naomi E. Allen, Timothy J. Key, Mazda Jenab, Elio Riboli

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates pheterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.

Lingua originale	Inglese
pagine (da-a)	912-923
Numero di pagine	12
Rivista	American Journal of Epidemiology
Volume	166
Numero di pubblicazione	8
DOI	https://doi.org/10.1093/aje/kwm161
Stato di pubblicazione	Pubblicato - ott 2007
Pubblicato esternamente	Sì

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Cust, A. E., Slimani, N., Kaaks, R., Van Bakel, M., Biessy, C., Ferrari, P., Laville, M., Tjønneland, A., Olsen, A., Overvad, K., Lajous, M., Clavel-Chapelon, F., Boutron-Ruault, M. C., Linseisen, J., Rohrmann, S., Nöthlings, U., Boeing, H., Palli, D., Sieri, S., ... Riboli, E. (2007). Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort. American Journal of Epidemiology, 166(8), 912-923. https://doi.org/10.1093/aje/kwm161

@article{f9e73589ec4a4d91b59f52b658b9a12a,

title = "Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort",

abstract = "The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95\% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95\% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95\% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95\% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates pheterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.",

keywords = "Cohort studies, Diet, Dietary carbohydrates, Dietary fiber, Endometrial neoplasms, Glycemic index, Insulin, Nutrition assessment",

author = "Cust, \{Anne E.\} and Nadia Slimani and Rudolf Kaaks and \{Van Bakel\}, Marit and Carine Biessy and Pietro Ferrari and Martine Laville and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Martin Lajous and Francoise Clavel-Chapelon and Boutron-Ruault, \{Marie Christine\} and Jakob Linseisen and Sabine Rohrmann and Ute N{\"o}thlings and Heiner Boeing and Domenico Palli and Sabina Sieri and Salvatore Panico and Rosario Tumino and Carlotta Sacerdote and Guri Skeie and Dagrun Engeset and Gram, \{Inger Torhild\} and Quir{\'o}s, \{J. Ram{\'o}n\} and Paula Jakszyn and S{\'a}nchez, \{Mar{\'i}a Jos{\'e}\} and Nerea Larra{\~n}aga and Carmen Navarro and Eva Ardanaz and Elisabet Wirf{\"a}lt and G{\"o}ran Berglund and Eva Lundin and G{\"o}ran Hallmans and Bueno-De-Mesquita, \{H. Bas\} and Huaidong Du and Peeters, \{Petra H.M.\} and Sheila Bingham and Khaw, \{Kay Tee\} and Allen, \{Naomi E.\} and Key, \{Timothy J.\} and Mazda Jenab and Elio Riboli",

year = "2007",

month = oct,

doi = "10.1093/aje/kwm161",

language = "English",

volume = "166",

pages = "912--923",

journal = "American Journal of Epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "8",

}

Cust, AE, Slimani, N, Kaaks, R, Van Bakel, M, Biessy, C, Ferrari, P, Laville, M, Tjønneland, A, Olsen, A, Overvad, K, Lajous, M, Clavel-Chapelon, F, Boutron-Ruault, MC, Linseisen, J, Rohrmann, S, Nöthlings, U, Boeing, H, Palli, D, Sieri, S, Panico, S, Tumino, R, Sacerdote, C, Skeie, G, Engeset, D, Gram, IT, Quirós, JR, Jakszyn, P, Sánchez, MJ, Larrañaga, N, Navarro, C, Ardanaz, E, Wirfält, E, Berglund, G, Lundin, E, Hallmans, G, Bueno-De-Mesquita, HB, Du, H, Peeters, PHM, Bingham, S, Khaw, KT, Allen, NE, Key, TJ, Jenab, M & Riboli, E 2007, 'Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort', American Journal of Epidemiology, vol. 166, n. 8, pagg. 912-923. https://doi.org/10.1093/aje/kwm161

Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort. / Cust, Anne E.; Slimani, Nadia; Kaaks, Rudolf et al.
In: American Journal of Epidemiology, Vol. 166, N. 8, 10.2007, pag. 912-923.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort

AU - Cust, Anne E.

AU - Slimani, Nadia

AU - Kaaks, Rudolf

AU - Van Bakel, Marit

AU - Biessy, Carine

AU - Ferrari, Pietro

AU - Laville, Martine

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Lajous, Martin

AU - Clavel-Chapelon, Francoise

AU - Boutron-Ruault, Marie Christine

AU - Linseisen, Jakob

AU - Rohrmann, Sabine

AU - Nöthlings, Ute

AU - Boeing, Heiner

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Skeie, Guri

AU - Engeset, Dagrun

AU - Gram, Inger Torhild

AU - Quirós, J. Ramón

AU - Jakszyn, Paula

AU - Sánchez, María José

AU - Larrañaga, Nerea

AU - Navarro, Carmen

AU - Ardanaz, Eva

AU - Wirfält, Elisabet

AU - Berglund, Göran

AU - Lundin, Eva

AU - Hallmans, Göran

AU - Bueno-De-Mesquita, H. Bas

AU - Du, Huaidong

AU - Peeters, Petra H.M.

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Allen, Naomi E.

AU - Key, Timothy J.

AU - Jenab, Mazda

AU - Riboli, Elio

PY - 2007/10

Y1 - 2007/10

N2 - The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates pheterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.

AB - The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates pheterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.

KW - Cohort studies

KW - Diet

KW - Dietary carbohydrates

KW - Dietary fiber

KW - Endometrial neoplasms

KW - Glycemic index

KW - Insulin

KW - Nutrition assessment

UR - http://www.scopus.com/inward/record.url?scp=34848886867&partnerID=8YFLogxK

U2 - 10.1093/aje/kwm161

DO - 10.1093/aje/kwm161

M3 - Article

SN - 0002-9262

VL - 166

SP - 912

EP - 923

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 8

ER -

Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort

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