Diagnostic usefulness of acute-phase protein measurement in hepatocellular carcinoma

Carlo Fabris; Mario Pirisi; Giorgio Soardo; Pierluigi Toniutto; Edmondo Falleti; Daniela Vitulli; Francesca Pezzetta; Fabio Gonano; Ettore Bartoli

doi:10.3109/07357909609018884

Diagnostic usefulness of acute-phase protein measurement in hepatocellular carcinoma

Carlo Fabris, Mario Pirisi, Giorgio Soardo, Pierluigi Toniutto, Edmondo Falleti, Daniela Vitulli, Francesca Pezzetta, Fabio Gonano, Ettore Bartoli

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

To compare the diagnostic usefulness as markers of hepatocellular carcinoma (HCC) of α₁-antitrypsin, C-reactive protein, and α₁-acid glycoprotein (all determined by nephelometric methods), we studied 132 subjects (74 male, 58 female): 43 had mild chronic liver disease, 32 cirrhosis, 24 HCC; 33 were controls. A total of 29.2% of the patients with HCC had α₁-acid glycoprotein > 100 mg/dl, 75.0% had α₁-antitrypsin > 220 mg/dl, 70.8% had C-reactive protein > 5 mg/L. In cirrhotics, frequencies were 3.1, 50.0 and 59.4%, respectively; in patients with mild chronic liver disease, 14.0, 11.6, and 32.6% (χ² 12.3; p < 0.01; χ² 47.3, p < 0.0001; χ² 38.0, p < 0.0001, respectively). α₁-fetoprotein performed better than all acute-phase proteins. We conclude that, due to their low specificity and/or sensitivity, none of the three acute-phase reactants tested can be recommended for diagnostic use as biological markers of HCC in Western patients.

Lingua originale	Inglese
pagine (da-a)	103-108
Numero di pagine	6
Rivista	Cancer Investigation
Volume	14
Numero di pubblicazione	2
DOI	https://doi.org/10.3109/07357909609018884
Stato di pubblicazione	Pubblicato - 1996
Pubblicato esternamente	Sì

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@article{c786681ff682493982c7920314702a31,

title = "Diagnostic usefulness of acute-phase protein measurement in hepatocellular carcinoma",

abstract = "To compare the diagnostic usefulness as markers of hepatocellular carcinoma (HCC) of α1-antitrypsin, C-reactive protein, and α1-acid glycoprotein (all determined by nephelometric methods), we studied 132 subjects (74 male, 58 female): 43 had mild chronic liver disease, 32 cirrhosis, 24 HCC; 33 were controls. A total of 29.2% of the patients with HCC had α1-acid glycoprotein > 100 mg/dl, 75.0% had α1-antitrypsin > 220 mg/dl, 70.8% had C-reactive protein > 5 mg/L. In cirrhotics, frequencies were 3.1, 50.0 and 59.4%, respectively; in patients with mild chronic liver disease, 14.0, 11.6, and 32.6% (χ2 12.3; p < 0.01; χ2 47.3, p < 0.0001; χ2 38.0, p < 0.0001, respectively). α1-fetoprotein performed better than all acute-phase proteins. We conclude that, due to their low specificity and/or sensitivity, none of the three acute-phase reactants tested can be recommended for diagnostic use as biological markers of HCC in Western patients.",

author = "Carlo Fabris and Mario Pirisi and Giorgio Soardo and Pierluigi Toniutto and Edmondo Falleti and Daniela Vitulli and Francesca Pezzetta and Fabio Gonano and Ettore Bartoli",

year = "1996",

doi = "10.3109/07357909609018884",

language = "English",

volume = "14",

pages = "103--108",

journal = "Cancer Investigation",

issn = "0735-7907",

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TY - JOUR

T1 - Diagnostic usefulness of acute-phase protein measurement in hepatocellular carcinoma

AU - Fabris, Carlo

AU - Pirisi, Mario

AU - Soardo, Giorgio

AU - Toniutto, Pierluigi

AU - Falleti, Edmondo

AU - Vitulli, Daniela

AU - Pezzetta, Francesca

AU - Gonano, Fabio

AU - Bartoli, Ettore

PY - 1996

Y1 - 1996

N2 - To compare the diagnostic usefulness as markers of hepatocellular carcinoma (HCC) of α1-antitrypsin, C-reactive protein, and α1-acid glycoprotein (all determined by nephelometric methods), we studied 132 subjects (74 male, 58 female): 43 had mild chronic liver disease, 32 cirrhosis, 24 HCC; 33 were controls. A total of 29.2% of the patients with HCC had α1-acid glycoprotein > 100 mg/dl, 75.0% had α1-antitrypsin > 220 mg/dl, 70.8% had C-reactive protein > 5 mg/L. In cirrhotics, frequencies were 3.1, 50.0 and 59.4%, respectively; in patients with mild chronic liver disease, 14.0, 11.6, and 32.6% (χ2 12.3; p < 0.01; χ2 47.3, p < 0.0001; χ2 38.0, p < 0.0001, respectively). α1-fetoprotein performed better than all acute-phase proteins. We conclude that, due to their low specificity and/or sensitivity, none of the three acute-phase reactants tested can be recommended for diagnostic use as biological markers of HCC in Western patients.

AB - To compare the diagnostic usefulness as markers of hepatocellular carcinoma (HCC) of α1-antitrypsin, C-reactive protein, and α1-acid glycoprotein (all determined by nephelometric methods), we studied 132 subjects (74 male, 58 female): 43 had mild chronic liver disease, 32 cirrhosis, 24 HCC; 33 were controls. A total of 29.2% of the patients with HCC had α1-acid glycoprotein > 100 mg/dl, 75.0% had α1-antitrypsin > 220 mg/dl, 70.8% had C-reactive protein > 5 mg/L. In cirrhotics, frequencies were 3.1, 50.0 and 59.4%, respectively; in patients with mild chronic liver disease, 14.0, 11.6, and 32.6% (χ2 12.3; p < 0.01; χ2 47.3, p < 0.0001; χ2 38.0, p < 0.0001, respectively). α1-fetoprotein performed better than all acute-phase proteins. We conclude that, due to their low specificity and/or sensitivity, none of the three acute-phase reactants tested can be recommended for diagnostic use as biological markers of HCC in Western patients.

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U2 - 10.3109/07357909609018884

DO - 10.3109/07357909609018884

M3 - Article

SN - 0735-7907

VL - 14

SP - 103

EP - 108

JO - Cancer Investigation

JF - Cancer Investigation

IS - 2

ER -

Diagnostic usefulness of acute-phase protein measurement in hepatocellular carcinoma

Abstract

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