Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Clara Cena; Donatella Boschi; Gian Cesare Tron; Kostantin Chegaev; Loretta Lazzarato; Antonella Di Stilo; Manuela Aragno; Roberta Fruttero; Alberto Gasco

doi:10.1016/j.bmcl.2004.10.006

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Clara Cena, Donatella Boschi, Gian Cesare Tron, Kostantin Chegaev, Loretta Lazzarato, Antonella Di Stilo, Manuela Aragno, Roberta Fruttero, Alberto Gasco

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.

Lingua originale	Inglese
pagine (da-a)	5971-5974
Numero di pagine	4
Rivista	Bioorganic and Medicinal Chemistry Letters
Volume	14
Numero di pubblicazione	24
DOI	https://doi.org/10.1016/j.bmcl.2004.10.006
Stato di pubblicazione	Pubblicato - 20 dic 2004

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10.1016/j.bmcl.2004.10.006

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title = "Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants",

abstract = "A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.",

keywords = "NO donors, NO-donor phenol antioxidants, Nitric oxide, Phenol antioxidants",

author = "Clara Cena and Donatella Boschi and Tron, {Gian Cesare} and Kostantin Chegaev and Loretta Lazzarato and Stilo, {Antonella Di} and Manuela Aragno and Roberta Fruttero and Alberto Gasco",

note = "Funding Information: This study was supported by a MIUR grant.",

year = "2004",

month = dec,

day = "20",

doi = "10.1016/j.bmcl.2004.10.006",

language = "English",

volume = "14",

pages = "5971--5974",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Development of a new class of potential antiatherosclerosis agents

T2 - NO-donor antioxidants

AU - Cena, Clara

AU - Boschi, Donatella

AU - Tron, Gian Cesare

AU - Chegaev, Kostantin

AU - Lazzarato, Loretta

AU - Stilo, Antonella Di

AU - Aragno, Manuela

AU - Fruttero, Roberta

AU - Gasco, Alberto

N1 - Funding Information: This study was supported by a MIUR grant.

PY - 2004/12/20

Y1 - 2004/12/20

N2 - A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.

AB - A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.

KW - NO donors

KW - NO-donor phenol antioxidants

KW - Nitric oxide

KW - Phenol antioxidants

UR - http://www.scopus.com/inward/record.url?scp=8844265397&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2004.10.006

DO - 10.1016/j.bmcl.2004.10.006

M3 - Article

SN - 0960-894X

VL - 14

SP - 5971

EP - 5974

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Abstract

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