TY - JOUR
T1 - Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma
AU - Kelly, Rachel S.
AU - Roulland, Sandrine
AU - Morgado, Ester
AU - Sungalee, Stéphanie
AU - Jouve, Nathalie
AU - Tumino, Rosario
AU - Krogh, Vittorio
AU - Panico, Salvatore
AU - Polidoro, Silvia
AU - Masala, Giovanna
AU - Sánchez, María José
AU - Chirlaque, Maria Dolores
AU - Sala, Núria
AU - Gurrea, Aurelio Barricarte
AU - Dorronsoro, Miren
AU - Travis, Ruth C.
AU - Riboli, Elio
AU - Gunter, Marc
AU - Murphy, Neil
AU - Vermeulen, Roel
AU - Bueno-de-Mesquita, H. B.
AU - Peeters, Petra H.
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Lagiou, Pagona
AU - Nieters, Alexandra
AU - Canzian, Federico
AU - Kaaks, Rudolf
AU - Boeing, Heiner
AU - Weiderpass, Elisabete
AU - Stocks, Tanja
AU - Melin, Beatrice
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Brennan, Paul
AU - Johansson, Mattias
AU - Nadel, Bertrand
AU - Vineis, Paolo
N1 - Publisher Copyright:
© 2015, Springer International Publishing Switzerland.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Purpose: The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established. Methods: t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case–control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)+ as compared to t(14;18)− cases. Results: Among incident FL cases, educational level (χ2p = 0.021) and height (χ2p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)HF] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)+ FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)− cases. Conclusions: These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.
AB - Purpose: The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established. Methods: t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case–control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)+ as compared to t(14;18)− cases. Results: Among incident FL cases, educational level (χ2p = 0.021) and height (χ2p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)HF] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)+ FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)− cases. Conclusions: These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.
KW - Follicular lymphoma
KW - Height
KW - Translocation
KW - t(14;18)
UR - https://www.scopus.com/pages/publications/84945349049
U2 - 10.1007/s10552-015-0677-2
DO - 10.1007/s10552-015-0677-2
M3 - Article
SN - 0957-5243
VL - 26
SP - 1845
EP - 1855
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 12
ER -
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