@article{ff7a1e15e278499da77838cdbdc158c0,
title = "Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase",
abstract = "New dimethylamino truncated squalene ether derivatives containing a different aromatic moiety (phenyl, naphthyl, and biphenyl) or a simple alkyl (n-hexylic) group were synthesized as inhibitors of the oxidosqualene cyclase (OSC) and of the sterol biosynthetic pathway. The activity against human OSC was compared with the activity against the OSCs of pathogenic organisms such as Pneumocystis carinii and Trypanosoma cruzi. The phenyl derivative was the most potent inhibitor of T. cruzi OSC.",
keywords = "Chagas disease, Lanosterol synthase, Oxidosqualene cyclase, Truncated squalene derivatives, Trypanosoma cruzi",
author = "Ubaldina Galli and Simonetta Oliaro-Bosso and Silvia Taramino and Serena Venegoni and Emanuele Pastore and Tron, {Gian Cesare} and Gianni Balliano and Franca Viola and Giovanni Sorba",
note = "Funding Information: Financial support from Universit{\`a} del Piemonte Orientale and the Ministero dell{\textquoteright}Istruzione, Universit{\`a} e Ricerca (MIUR), Italy (ex 60%), is gratefully acknowledged. Thanks are due to Professor Seiichi Matsuda (Rice University, Houston, TX, USA) for supplying S. cerevisiae strains SMY8[pBJ1.21], expressing the OSC of T. cruzi; SMY8[pSM61.21], expressing the wild-type yeast OSC; SMY8[pBJ4.21] expressing the P. carinii OSC and to Ralf Thoma (Hoffmann-La Roche Ltd, Pharma Discovery Research CH 4070, Basel, Switzerland) for supplying the Pichia pastoris strain expressing the human OSC.",
year = "2007",
month = jan,
day = "1",
doi = "10.1016/j.bmcl.2006.09.058",
language = "English",
volume = "17",
pages = "220--224",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "1",
}
