Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma

Paola Bonetti; Monica Testoni; Marta Scandurra; Maurilio Ponzoni; Roberto Piva; Afua A. Mensah; Andrea Rinaldi; Ivo Kwee; Maria Grazia Tibiletti; Javeed Iqbal; Timothy C. Greiner; Wing Chung Chan; Gianluca Gaidano; Miguel A. Piris; Franco Cavalli; Emanuele Zucca; Giorgio Inghirami; Francesco Bertoni

doi:10.1182/blood-2013-01-475772

Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma

Paola Bonetti, Monica Testoni, Marta Scandurra, Maurilio Ponzoni, Roberto Piva, Afua A. Mensah, Andrea Rinaldi, Ivo Kwee, Maria Grazia Tibiletti, Javeed Iqbal, Timothy C. Greiner, Wing Chung Chan, Gianluca Gaidano, Miguel A. Piris, Franco Cavalli, Emanuele Zucca, Giorgio Inghirami, Francesco Bertoni

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. DLBCL is a heterogeneous disease characterized by different genetic lesions. We herein report the functional characterization of a recurrent gain mapping on chromosome 11q24.3, found in 23% of 166 DLBCL cases analyzed. The transcription factors ETS1 and FLI1, located within the 11q24.3 region, had significantly higher expression in clinical samples carrying the gain. Functional studies on cell lines showed that ETS1 and FLI1 cooperate in sustaining DLBCL proliferation and viability and regulate genes involved in germinal center differentiation. Taken together, these data identify the 11q24.3 gain as a recurrent lesion in DLBCL leading to ETS1 and FLI1 deregulated expression, which can contribute to the pathogenesis of this disease.

Lingua originale	Inglese
pagine (da-a)	2233-2241
Numero di pagine	9
Rivista	Blood
Volume	122
Numero di pubblicazione	13
DOI	https://doi.org/10.1182/blood-2013-01-475772
Stato di pubblicazione	Pubblicato - 2013

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Bonetti, P., Testoni, M., Scandurra, M., Ponzoni, M., Piva, R., Mensah, A. A., Rinaldi, A., Kwee, I., Tibiletti, M. G., Iqbal, J., Greiner, T. C., Chan, W. C., Gaidano, G., Piris, M. A., Cavalli, F., Zucca, E., Inghirami, G., & Bertoni, F. (2013). Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma. Blood, 122(13), 2233-2241. https://doi.org/10.1182/blood-2013-01-475772

@article{eb8c8e40969a46a8b09c7038034e7570,

title = "Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma",

abstract = "Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. DLBCL is a heterogeneous disease characterized by different genetic lesions. We herein report the functional characterization of a recurrent gain mapping on chromosome 11q24.3, found in 23% of 166 DLBCL cases analyzed. The transcription factors ETS1 and FLI1, located within the 11q24.3 region, had significantly higher expression in clinical samples carrying the gain. Functional studies on cell lines showed that ETS1 and FLI1 cooperate in sustaining DLBCL proliferation and viability and regulate genes involved in germinal center differentiation. Taken together, these data identify the 11q24.3 gain as a recurrent lesion in DLBCL leading to ETS1 and FLI1 deregulated expression, which can contribute to the pathogenesis of this disease.",

author = "Paola Bonetti and Monica Testoni and Marta Scandurra and Maurilio Ponzoni and Roberto Piva and Mensah, {Afua A.} and Andrea Rinaldi and Ivo Kwee and Tibiletti, {Maria Grazia} and Javeed Iqbal and Greiner, {Timothy C.} and Chan, {Wing Chung} and Gianluca Gaidano and Piris, {Miguel A.} and Franco Cavalli and Emanuele Zucca and Giorgio Inghirami and Francesco Bertoni",

note = "Publisher Copyright: {\textcopyright} 2013 by The American Society of Hematology.",

year = "2013",

doi = "10.1182/blood-2013-01-475772",

language = "English",

volume = "122",

pages = "2233--2241",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier B.V.",

number = "13",

}

Bonetti, P, Testoni, M, Scandurra, M, Ponzoni, M, Piva, R, Mensah, AA, Rinaldi, A, Kwee, I, Tibiletti, MG, Iqbal, J, Greiner, TC, Chan, WC, Gaidano, G, Piris, MA, Cavalli, F, Zucca, E, Inghirami, G & Bertoni, F 2013, 'Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma', Blood, vol. 122, n. 13, pagg. 2233-2241. https://doi.org/10.1182/blood-2013-01-475772

TY - JOUR

T1 - Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma

AU - Bonetti, Paola

AU - Testoni, Monica

AU - Scandurra, Marta

AU - Ponzoni, Maurilio

AU - Piva, Roberto

AU - Mensah, Afua A.

AU - Rinaldi, Andrea

AU - Kwee, Ivo

AU - Tibiletti, Maria Grazia

AU - Iqbal, Javeed

AU - Greiner, Timothy C.

AU - Chan, Wing Chung

AU - Gaidano, Gianluca

AU - Piris, Miguel A.

AU - Cavalli, Franco

AU - Zucca, Emanuele

AU - Inghirami, Giorgio

AU - Bertoni, Francesco

PY - 2013

Y1 - 2013

N2 - Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. DLBCL is a heterogeneous disease characterized by different genetic lesions. We herein report the functional characterization of a recurrent gain mapping on chromosome 11q24.3, found in 23% of 166 DLBCL cases analyzed. The transcription factors ETS1 and FLI1, located within the 11q24.3 region, had significantly higher expression in clinical samples carrying the gain. Functional studies on cell lines showed that ETS1 and FLI1 cooperate in sustaining DLBCL proliferation and viability and regulate genes involved in germinal center differentiation. Taken together, these data identify the 11q24.3 gain as a recurrent lesion in DLBCL leading to ETS1 and FLI1 deregulated expression, which can contribute to the pathogenesis of this disease.

AB - Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. DLBCL is a heterogeneous disease characterized by different genetic lesions. We herein report the functional characterization of a recurrent gain mapping on chromosome 11q24.3, found in 23% of 166 DLBCL cases analyzed. The transcription factors ETS1 and FLI1, located within the 11q24.3 region, had significantly higher expression in clinical samples carrying the gain. Functional studies on cell lines showed that ETS1 and FLI1 cooperate in sustaining DLBCL proliferation and viability and regulate genes involved in germinal center differentiation. Taken together, these data identify the 11q24.3 gain as a recurrent lesion in DLBCL leading to ETS1 and FLI1 deregulated expression, which can contribute to the pathogenesis of this disease.

UR - http://www.scopus.com/inward/record.url?scp=84887368306&partnerID=8YFLogxK

U2 - 10.1182/blood-2013-01-475772

DO - 10.1182/blood-2013-01-475772

M3 - Article

SN - 0006-4971

VL - 122

SP - 2233

EP - 2241

JO - Blood

JF - Blood

IS - 13

ER -

Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma

Abstract

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