Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength

Valérie C. Pierre; Mauro Botta; Kenneth N. Raymond

doi:10.1021/ja045263y

Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength

Valérie C. Pierre, Mauro Botta, Kenneth N. Raymond

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp₂-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r_1p = 18 mM^-1 s^-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.

Lingua originale	Inglese
pagine (da-a)	504-505
Numero di pagine	2
Rivista	Journal of the American Chemical Society
Volume	127
Numero di pubblicazione	2
DOI	https://doi.org/10.1021/ja045263y
Stato di pubblicazione	Pubblicato - 19 gen 2005

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10.1021/ja045263y

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abstract = "The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.",

author = "Pierre, {Val{\'e}rie C.} and Mauro Botta and Raymond, {Kenneth N.}",

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AU - Raymond, Kenneth N.

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N2 - The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.

AB - The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.

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Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength

Abstract

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