TY - JOUR
T1 - Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase
AU - Costantino, Gabriele
AU - Natalini, Benedetto
AU - Pellicciari, Roberto
AU - Moroni, Flavio
AU - Lombard, Grazia
PY - 1993/10
Y1 - 1993/10
N2 - (2S,3S,4S)-α-Carboxycyclopropylglycine (l-CCG I) and trans-1-amino-(1S,3R)-cyclopentanedicarboxylic acid ((1S,3R)-ACPD), partially constrained l-glutamate analogs known to be agonists at the metabotropic glutamate receptors (mGluRs) adenylyl cyclase coupled, have been submitted to conformational analysis and the data obtained utilized to define a pharmacophore which takes into account the location of hydrogen bonding donating sites of the receptor. This pharmacophore has been utilized to define the agonist mGluRs↓cAMP bioactive conformation of l-Glu.
AB - (2S,3S,4S)-α-Carboxycyclopropylglycine (l-CCG I) and trans-1-amino-(1S,3R)-cyclopentanedicarboxylic acid ((1S,3R)-ACPD), partially constrained l-glutamate analogs known to be agonists at the metabotropic glutamate receptors (mGluRs) adenylyl cyclase coupled, have been submitted to conformational analysis and the data obtained utilized to define a pharmacophore which takes into account the location of hydrogen bonding donating sites of the receptor. This pharmacophore has been utilized to define the agonist mGluRs↓cAMP bioactive conformation of l-Glu.
UR - http://www.scopus.com/inward/record.url?scp=0027676557&partnerID=8YFLogxK
U2 - 10.1016/S0968-0896(00)82130-6
DO - 10.1016/S0968-0896(00)82130-6
M3 - Article
SN - 0968-0896
VL - 1
SP - 259
EP - 265
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 4
ER -