Decrease in rat cerebral quinolinic acid concentration following chronic hydrocortisone treatment

J. Connick; G. Lombardi; M. Beni; F. Moroni

doi:10.1016/0304-3940(88)90129-2

Decrease in rat cerebral quinolinic acid concentration following chronic hydrocortisone treatment

J. Connick, G. Lombardi, M. Beni, F. Moroni

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The effects of acute or repeated hydrocortisone administration were studied on the content of quinolinic acid (QUIN), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) assessed by mass fragmentography (QUIN) and high-performance liquid chromatography (5-HT and 5-HIAA) in various brain areas of the rat. Acute administration of the steroid did not significantly modify the brain content of these tryptophan metabolites while, when repeatedly administered at doses of 5 or 50 mg/kg i.p., hydrocortisone significantly reduced the cortical content of QUIN (by 28%, P < 0.05 and 21%, P < 0.05 respectively) and the utilization of 5-HT (as evaluated from the ratio 5-HIAA 5-HT by 22%, P < 0.05 at 50 mg/kg). These data confirm that hydrocortisone administration affects tryptophan metabolism in the rat.

Lingua originale	Inglese
pagine (da-a)	216-220
Numero di pagine	5
Rivista	Neuroscience Letters
Volume	88
Numero di pubblicazione	2
DOI	https://doi.org/10.1016/0304-3940(88)90129-2
Stato di pubblicazione	Pubblicato - 26 mag 1988
Pubblicato esternamente	Sì

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10.1016/0304-3940(88)90129-2

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title = "Decrease in rat cerebral quinolinic acid concentration following chronic hydrocortisone treatment",

abstract = "The effects of acute or repeated hydrocortisone administration were studied on the content of quinolinic acid (QUIN), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) assessed by mass fragmentography (QUIN) and high-performance liquid chromatography (5-HT and 5-HIAA) in various brain areas of the rat. Acute administration of the steroid did not significantly modify the brain content of these tryptophan metabolites while, when repeatedly administered at doses of 5 or 50 mg/kg i.p., hydrocortisone significantly reduced the cortical content of QUIN (by 28%, P < 0.05 and 21%, P < 0.05 respectively) and the utilization of 5-HT (as evaluated from the ratio 5-HIAA 5-HT by 22%, P < 0.05 at 50 mg/kg). These data confirm that hydrocortisone administration affects tryptophan metabolism in the rat.",

keywords = "Hydrocortisone, Quinolinic acid, Serotonin, Tryptophan",

author = "J. Connick and G. Lombardi and M. Beni and F. Moroni",

note = "Funding Information: Supportedb y the Universityo f Florencea nd Action Researchf or the Crippled Child (to Prof. T.W. Stone).J .C. was also supportedb y a travel grant from ETP. We thank Prof. T. Stonef or helpfuld iscussion.",

year = "1988",

month = may,

day = "26",

doi = "10.1016/0304-3940(88)90129-2",

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T1 - Decrease in rat cerebral quinolinic acid concentration following chronic hydrocortisone treatment

AU - Connick, J.

AU - Lombardi, G.

AU - Beni, M.

AU - Moroni, F.

N1 - Funding Information: Supportedb y the Universityo f Florencea nd Action Researchf or the Crippled Child (to Prof. T.W. Stone).J .C. was also supportedb y a travel grant from ETP. We thank Prof. T. Stonef or helpfuld iscussion.

PY - 1988/5/26

Y1 - 1988/5/26

N2 - The effects of acute or repeated hydrocortisone administration were studied on the content of quinolinic acid (QUIN), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) assessed by mass fragmentography (QUIN) and high-performance liquid chromatography (5-HT and 5-HIAA) in various brain areas of the rat. Acute administration of the steroid did not significantly modify the brain content of these tryptophan metabolites while, when repeatedly administered at doses of 5 or 50 mg/kg i.p., hydrocortisone significantly reduced the cortical content of QUIN (by 28%, P < 0.05 and 21%, P < 0.05 respectively) and the utilization of 5-HT (as evaluated from the ratio 5-HIAA 5-HT by 22%, P < 0.05 at 50 mg/kg). These data confirm that hydrocortisone administration affects tryptophan metabolism in the rat.

AB - The effects of acute or repeated hydrocortisone administration were studied on the content of quinolinic acid (QUIN), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) assessed by mass fragmentography (QUIN) and high-performance liquid chromatography (5-HT and 5-HIAA) in various brain areas of the rat. Acute administration of the steroid did not significantly modify the brain content of these tryptophan metabolites while, when repeatedly administered at doses of 5 or 50 mg/kg i.p., hydrocortisone significantly reduced the cortical content of QUIN (by 28%, P < 0.05 and 21%, P < 0.05 respectively) and the utilization of 5-HT (as evaluated from the ratio 5-HIAA 5-HT by 22%, P < 0.05 at 50 mg/kg). These data confirm that hydrocortisone administration affects tryptophan metabolism in the rat.

KW - Hydrocortisone

KW - Quinolinic acid

KW - Serotonin

KW - Tryptophan

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U2 - 10.1016/0304-3940(88)90129-2

DO - 10.1016/0304-3940(88)90129-2

M3 - Article

SN - 0304-3940

VL - 88

SP - 216

EP - 220

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Decrease in rat cerebral quinolinic acid concentration following chronic hydrocortisone treatment

Abstract

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