TY - JOUR
T1 - De Novo Malignancy after Liver Transplantation
T2 - Risk Assessment, Prevention, and Management - Guidelines from the ILTS-SETH Consensus Conference
AU - Colmenero, Jordi
AU - Tabrizian, Parissa
AU - Bhangui, Prashant
AU - Pinato, David James
AU - Rodríguez-Perálvarez, Manuel L.
AU - Sapisochin, Gonzalo
AU - Bhoori, Sherrie
AU - Pascual, Sonia
AU - Senzolo, Marco
AU - Al-Adra, David
AU - Herrero, J. Ignacio
AU - Petrowsky, Henrik
AU - Dawson, Laura A.
AU - Hosni, Ali
AU - Kutzke, Jade L.
AU - Gastaca, Mikel
AU - Watt, Kymberly D.
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - De novo malignancies (DNMs) following liver transplantation (LT) have been reported as 1 of the major causes of late mortality, being the most common cause of death in the second decade after LT. The overall incidence of DNMs is reported to be in the range of 3.1% to 14.4%, and the incidence is 2- to 3-fold higher in transplant recipients than in age- and sex-matched healthy controls. Long-term immunosuppressive therapy, which is the key in maintaining host tolerance and achieving good long-term outcomes, is known to contribute to a higher risk of DNMs. However, the incidence and type of DNM also depends on different risk factors, including patient demographics, cause of the underlying chronic liver disease, behavior (smoking and alcohol abuse), and pre-existing premalignant conditions. The estimated standardized incidence ratio for different DNMs is also variable. The International Liver Transplantation Society-Spanish Society of Liver Transplantation Consensus Conference working group on DNM has summarized and discussed the current available literature on epidemiology, risk factors, management, and survival after DNMs. Recommendations for screening and surveillance for specific tumors, as well as immunosuppression and cancer-specific management in patients with DNM, are summarized.
AB - De novo malignancies (DNMs) following liver transplantation (LT) have been reported as 1 of the major causes of late mortality, being the most common cause of death in the second decade after LT. The overall incidence of DNMs is reported to be in the range of 3.1% to 14.4%, and the incidence is 2- to 3-fold higher in transplant recipients than in age- and sex-matched healthy controls. Long-term immunosuppressive therapy, which is the key in maintaining host tolerance and achieving good long-term outcomes, is known to contribute to a higher risk of DNMs. However, the incidence and type of DNM also depends on different risk factors, including patient demographics, cause of the underlying chronic liver disease, behavior (smoking and alcohol abuse), and pre-existing premalignant conditions. The estimated standardized incidence ratio for different DNMs is also variable. The International Liver Transplantation Society-Spanish Society of Liver Transplantation Consensus Conference working group on DNM has summarized and discussed the current available literature on epidemiology, risk factors, management, and survival after DNMs. Recommendations for screening and surveillance for specific tumors, as well as immunosuppression and cancer-specific management in patients with DNM, are summarized.
UR - http://www.scopus.com/inward/record.url?scp=85121903661&partnerID=8YFLogxK
U2 - 10.1097/TP.0000000000003998
DO - 10.1097/TP.0000000000003998
M3 - Article
SN - 0041-1337
VL - 106
SP - E30-E45
JO - Transplantation
JF - Transplantation
IS - 1
ER -