Cytoskeletal alterations in human platelets exposed to oxidative stress are mediated by oxidative and Ca²⁺-dependent mechanisms

Keyphrases

• Platelets 100%
• Human Platelets 100%
• Oxidative Stress 100%
• Menadione 100%
• Ca2+ Dependence 100%
• Cytoskeletal Alterations 100%
• Cytoskeletal Proteins 80%
• Incubation Media 40%
• Cytosolic Ca2+ 40%
• Actin 40%
• Protein Thiols 40%
• Actin-binding Proteins 40%
• Metabolism 20%
• Cytosolic Ca2+ Concentration 20%
• Ca2+ 20%
• High Concentration 20%
• Polypeptide 20%
• Polyacrylamide Gel Electrophoresis 20%
• High Molecular Weight 20%
• Dose Effect 20%
• 2-Hydroxy-1,4-naphthoquinone 20%
• Quin-2 20%
• Esters 20%
• Relative Amount 20%
• Oxidative Modification 20%
• Redox-active 20%
• Relative Abundance 20%
• Protein Modification 20%
• Reducing Conditions 20%
• Leupeptin 20%
• Incubation Conditions 20%
• Trimer 20%
• Superoxide Anion Production 20%
• Quinones 20%
• Multiple Effects 20%
• Protease Inhibitors 20%
• Actinin 20%
• Cytoskeleton 20%
• 2-mercaptoethanol 20%
• Intracellular Glutathione 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Calcium Ion 100%
• Menadione 100%
• Cytoskeleton Protein 50%
• Actin 33%
• Actin Binding Protein 33%
• Thiol 33%
• Polyacrylamide Gel Electrophoresis 16%
• Buffer 16%
• Quinone Derivative 16%
• Polypeptide 16%
• Superoxide 16%
• Glutathione 16%
• 2-Mercaptoethanol 16%
• Proteinase Inhibitor 16%
• Quin 2 AM 16%
• Actinin 16%
• Dimer 16%
• Leupeptin 16%