Cutaneous metastasis of neuroendocrine carcinoma of the larynx: Report of a case

Antonio Ottinetti, E. Colombo, F. Dardano, P. Migliora, F. Picciotto, A. Zaccagna, G. Angeli

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Background: Cutaneous metastasis from neuroendocrine carcinomas of visceral origin is rarely described in indexed literature. The primary sites of origin include: lung (Wick et al., J Am Acad Dermatol 1985; 13: 134), larynx (Zambruno et al., Ann Dermatol Venereol 1989; 116: 855; Schmidt et al., J Laryngol Otol 1994; 108: 272; Guerzider et al., Ann Pathol 1991; 11 (4): 253), mediastinum (Yoshimasu et al., J Dermatol 2001; 28 (3): 168), uterus (Fogaca et al., J Cutan Pathol 1993; 20: 455), and thymus (Wick et al., J Am Acad Dermatol 1985; 13: 134). Methods: In this report, the authors present the clinical, histological, immunohistochemical, and ultrastructural characteristics of secondary skin localizations of a neuroendocrine laryngeal tumor that occurred in a 61-year-old man. The complete follow up of the case is described and a brief revision of the terminology and classification of neuroendocrine neoplasms of the larynx is discussed, since a significant relationship exists between the degree of differentiation and biological behavior. Results: On histological examination, the secondary cutaneous localization appeared to be more dedifferentiated compared to the primary tumor. The immunohistochemical patterns of reactivity were similar in both neoplasms, showing expression of neuroendocrine and epithelial markers. Conclusions: An important issue of prognostic significance is to differentiate a cutaneous metastasis of a neuroendocrine carcinoma from the primary small cell-undifferentiated carcinoma of the skin (Merkel cell carcinoma).

Lingua originaleInglese
pagine (da-a)512-515
Numero di pagine4
RivistaJournal of Cutaneous Pathology
Volume30
Numero di pubblicazione8
DOI
Stato di pubblicazionePubblicato - set 2003
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'Cutaneous metastasis of neuroendocrine carcinoma of the larynx: Report of a case'. Insieme formano una fingerprint unica.

Cita questo