ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer

David J. Pinato; Pasquale Lombardi; Antonio D’Alessio; Aria Torkpour; Claudia Angela Maria Fulgenzi; Leonardo Brunetti

doi:10.1158/1078-0432.CCR-24-3805

ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer

David J. Pinato
, Pasquale Lombardi
, Antonio D’Alessio
, Aria Torkpour
, Claudia Angela Maria Fulgenzi
, Leonardo Brunetti

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Although deemed potentially curative, surgical resection of hepatocellular carcinoma is associated with >70% risk of postoperative relapse. Recurrence is uniquely multifactorial in hepatocellular carcinoma, potentially stemming from metachronous reoccurrence of the original tumor or de novo cancerization. ctDNA may improve personalized risk stratification after resection, a setting where adjuvant immunotherapy has failed to provide survival benefit.

Lingua originale	Inglese
pagine (da-a)	955-957
Numero di pagine	3
Rivista	Clinical Cancer Research
Volume	31
Numero di pubblicazione	6
DOI	https://doi.org/10.1158/1078-0432.CCR-24-3805
Stato di pubblicazione	Pubblicato - 15 mar 2025

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10.1158/1078-0432.CCR-24-3805

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title = "ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer",

abstract = "Although deemed potentially curative, surgical resection of hepatocellular carcinoma is associated with >70\% risk of postoperative relapse. Recurrence is uniquely multifactorial in hepatocellular carcinoma, potentially stemming from metachronous reoccurrence of the original tumor or de novo cancerization. ctDNA may improve personalized risk stratification after resection, a setting where adjuvant immunotherapy has failed to provide survival benefit.",

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AU - Pinato, David J.

AU - Lombardi, Pasquale

AU - D’Alessio, Antonio

AU - Torkpour, Aria

AU - Fulgenzi, Claudia Angela Maria

AU - Brunetti, Leonardo

PY - 2025/3/15

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AB - Although deemed potentially curative, surgical resection of hepatocellular carcinoma is associated with >70% risk of postoperative relapse. Recurrence is uniquely multifactorial in hepatocellular carcinoma, potentially stemming from metachronous reoccurrence of the original tumor or de novo cancerization. ctDNA may improve personalized risk stratification after resection, a setting where adjuvant immunotherapy has failed to provide survival benefit.

UR - https://www.scopus.com/pages/publications/105001219676

U2 - 10.1158/1078-0432.CCR-24-3805

DO - 10.1158/1078-0432.CCR-24-3805

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JO - Clinical Cancer Research

JF - Clinical Cancer Research

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ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer

Abstract

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