ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer

David J. Pinato; Pasquale Lombardi; Antonio D’Alessio; Aria Torkpour; Claudia Angela Maria Fulgenzi; Leonardo Brunetti

doi:10.1158/1078-0432.CCR-24-3805

ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer

David J. Pinato, Pasquale Lombardi, Antonio D’Alessio, Aria Torkpour, Claudia Angela Maria Fulgenzi, Leonardo Brunetti

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Although deemed potentially curative, surgical resection of hepatocellular carcinoma is associated with >70% risk of postoperative relapse. Recurrence is uniquely multifactorial in hepatocellular carcinoma, potentially stemming from metachronous reoccurrence of the original tumor or de novo cancerization. ctDNA may improve personalized risk stratification after resection, a setting where adjuvant immunotherapy has failed to provide survival benefit.

Lingua originale	Inglese
pagine (da-a)	955-957
Numero di pagine	3
Rivista	Clinical Cancer Research
Volume	31
Numero di pubblicazione	6
DOI	https://doi.org/10.1158/1078-0432.CCR-24-3805
Stato di pubblicazione	Pubblicato - 15 mar 2025

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1158/1078-0432.CCR-24-3805

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{eff7996752e949cabf23ba951d3e5220,

title = "ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer",

abstract = "Although deemed potentially curative, surgical resection of hepatocellular carcinoma is associated with >70\% risk of postoperative relapse. Recurrence is uniquely multifactorial in hepatocellular carcinoma, potentially stemming from metachronous reoccurrence of the original tumor or de novo cancerization. ctDNA may improve personalized risk stratification after resection, a setting where adjuvant immunotherapy has failed to provide survival benefit.",

author = "Pinato, \{David J.\} and Pasquale Lombardi and Antonio D{\textquoteright}Alessio and Aria Torkpour and Fulgenzi, \{Claudia Angela Maria\} and Leonardo Brunetti",

note = "Publisher Copyright: {\textcopyright} 2025 American Association for Cancer Research.",

year = "2025",

month = mar,

day = "15",

doi = "10.1158/1078-0432.CCR-24-3805",

language = "English",

volume = "31",

pages = "955--957",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

number = "6",

}

TY - JOUR

T1 - ctDNA

T2 - A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer

AU - Pinato, David J.

AU - Lombardi, Pasquale

AU - D’Alessio, Antonio

AU - Torkpour, Aria

AU - Fulgenzi, Claudia Angela Maria

AU - Brunetti, Leonardo

PY - 2025/3/15

Y1 - 2025/3/15

N2 - Although deemed potentially curative, surgical resection of hepatocellular carcinoma is associated with >70% risk of postoperative relapse. Recurrence is uniquely multifactorial in hepatocellular carcinoma, potentially stemming from metachronous reoccurrence of the original tumor or de novo cancerization. ctDNA may improve personalized risk stratification after resection, a setting where adjuvant immunotherapy has failed to provide survival benefit.

AB - Although deemed potentially curative, surgical resection of hepatocellular carcinoma is associated with >70% risk of postoperative relapse. Recurrence is uniquely multifactorial in hepatocellular carcinoma, potentially stemming from metachronous reoccurrence of the original tumor or de novo cancerization. ctDNA may improve personalized risk stratification after resection, a setting where adjuvant immunotherapy has failed to provide survival benefit.

UR - https://www.scopus.com/pages/publications/105001219676

U2 - 10.1158/1078-0432.CCR-24-3805

DO - 10.1158/1078-0432.CCR-24-3805

M3 - Article

SN - 1078-0432

VL - 31

SP - 955

EP - 957

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 6

ER -

ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo