TY - JOUR
T1 - ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer
AU - PINATO, David James
AU - Lombardi, Pasquale
AU - D'Alessio, Antonio
AU - Torkpour, Aria
AU - Fulgenzi, Claudia Angela Maria
AU - Brunetti, Leonardo
PY - 2025
Y1 - 2025
N2 - : While deemed potentially curative, surgical resection of hepatocellular carcinoma (HCC) is associated with >70% risk of post-operative relapse. Recurrence is uniquely multifactorial in HCC, potentially stemming from metachronous re-occurrence of the original tumor or de novo cancerization. Circulating tumor DNA may improve personalized risk stratification post-resection, a setting where adjuvant immunotherapy has failed to provide survival benefits.
AB - : While deemed potentially curative, surgical resection of hepatocellular carcinoma (HCC) is associated with >70% risk of post-operative relapse. Recurrence is uniquely multifactorial in HCC, potentially stemming from metachronous re-occurrence of the original tumor or de novo cancerization. Circulating tumor DNA may improve personalized risk stratification post-resection, a setting where adjuvant immunotherapy has failed to provide survival benefits.
UR - https://iris.uniupo.it/handle/11579/202264
U2 - 10.1158/1078-0432.CCR-24-3805
DO - 10.1158/1078-0432.CCR-24-3805
M3 - Literature review
SN - 1078-0432
JO - Clinical Cancer Research
JF - Clinical Cancer Research
ER -
