Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia

Keyphrases

• Drug Target 100%
• Kynurenic Acid 100%
• Schizophrenia Treatment 100%
• Kynurenine Aminotransferase 100%
• Aspartate Aminotransferase 66%
• Structural Comparison 66%
• Rational Design 33%
• Functional Role 33%
• Catalytic Activity 33%
• Highly Selective 33%
• Active Sites 33%
• Neurological Diseases 33%
• Cognitive Impairment 33%
• Structural Difference 33%
• Human Brain 33%
• Ligand Binding 33%
• Pharmacological Data 33%
• Neuropathology 33%
• Aminotransferase 33%
• Schizophrenia 33%
• N-terminal Region 33%
• Highly Similar 33%
• Dispersion Method 33%
• Single-wavelength Anomalous Dispersion 33%
• KAT II 33%
• Neuroactive Steroids 33%
• Aromatic Cage 33%

Neuroscience

• Kynurenic Acid 100%
• Kynurenine Aminotransferase 100%
• Treatment of Schizophrenia 100%
• Aspartate Aminotransferase 66%
• Transaminase 33%
• Nervous System Disorder 33%
• Cognitive Disorders 33%
• Amino Terminal Sequence 33%
• Ligand Binding 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Kynurenic Acid 100%
• Kynurenine Aminotransferase 100%
• Aspartate Aminotransferase 66%
• Aminotransferase 33%
• Dimer 33%
• Cognitive Defect 33%
• Neurologic Disease 33%