TY - JOUR
T1 - Contemporary issues on clopidogrel therapy
AU - Patti, Giuseppe
AU - Di Sciascio, Germano
PY - 2009/6
Y1 - 2009/6
N2 - In this paper, data from available studies regarding some contemporary issues on clopidogrel therapy are analyzed. In particular, the following clinical questions have been considered and addressed: (a) Is early clopidogrel treatment needed in patients with acute coronary syndromes treated medically or undergoing percutaneous coronary intervention (PCI)? (b) What is the optimal clopidogrel loading dose in patients undergoing PCI? (c) Is pre-treatment with clopidogrel before PCI needed, or can clopidogrel loading be given in the catheter laboratory before intervention, but after coronary anatomy is known? (d) What is the optimal clopidogrel strategy in patients on chronic clopidogrel therapy undergoing PCI? (e) Does the degree of clopidogrel response influence clinical outcome in patients undergoing PCI?
AB - In this paper, data from available studies regarding some contemporary issues on clopidogrel therapy are analyzed. In particular, the following clinical questions have been considered and addressed: (a) Is early clopidogrel treatment needed in patients with acute coronary syndromes treated medically or undergoing percutaneous coronary intervention (PCI)? (b) What is the optimal clopidogrel loading dose in patients undergoing PCI? (c) Is pre-treatment with clopidogrel before PCI needed, or can clopidogrel loading be given in the catheter laboratory before intervention, but after coronary anatomy is known? (d) What is the optimal clopidogrel strategy in patients on chronic clopidogrel therapy undergoing PCI? (e) Does the degree of clopidogrel response influence clinical outcome in patients undergoing PCI?
KW - Acute coronary syndromes
KW - Clopidogrel
KW - Outcome
KW - Percutaneous coronary intervention
UR - http://www.scopus.com/inward/record.url?scp=67349144723&partnerID=8YFLogxK
U2 - 10.1007/s11739-008-0220-5
DO - 10.1007/s11739-008-0220-5
M3 - Review article
SN - 1828-0447
VL - 4
SP - 201
EP - 211
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
IS - 3
ER -