Construction of a genetic map telomeric to HLA-A by microsatellite analysis

C. Camaschella; A. Roetto; G. De Sandre; A. Piperno; A. Totaro; I. Dianzani; P. Gasparini

doi:10.1006/mcpr.1993.1060

Construction of a genetic map telomeric to HLA-A by microsatellite analysis

C. Camaschella, A. Roetto, G. De Sandre, A. Piperno, A. Totaro, I. Dianzani, P. Gasparini

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Allele and genotype frequencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0·65 to 0·78. Two point and three point linkage anlaysis among these markers and HLA-A serological types-available for all the studied samples-allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage analysis of genetic disorders mapping on this region of 6p.

Lingua originale	Inglese
pagine (da-a)	411-414
Numero di pagine	4
Rivista	Molecular and Cellular Probes
Volume	7
Numero di pubblicazione	5
DOI	https://doi.org/10.1006/mcpr.1993.1060
Stato di pubblicazione	Pubblicato - ott 1993
Pubblicato esternamente	Sì

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title = "Construction of a genetic map telomeric to HLA-A by microsatellite analysis",

abstract = "Allele and genotype frequencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0·65 to 0·78. Two point and three point linkage anlaysis among these markers and HLA-A serological types-available for all the studied samples-allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage analysis of genetic disorders mapping on this region of 6p.",

keywords = "Genetic map, linkage analysis, chromosome 6, microsatellites",

author = "C. Camaschella and A. Roetto and {De Sandre}, G. and A. Piperno and A. Totaro and I. Dianzani and P. Gasparini",

year = "1993",

month = oct,

doi = "10.1006/mcpr.1993.1060",

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T1 - Construction of a genetic map telomeric to HLA-A by microsatellite analysis

AU - Camaschella, C.

AU - Roetto, A.

AU - De Sandre, G.

AU - Piperno, A.

AU - Totaro, A.

AU - Dianzani, I.

AU - Gasparini, P.

PY - 1993/10

Y1 - 1993/10

N2 - Allele and genotype frequencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0·65 to 0·78. Two point and three point linkage anlaysis among these markers and HLA-A serological types-available for all the studied samples-allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage analysis of genetic disorders mapping on this region of 6p.

AB - Allele and genotype frequencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0·65 to 0·78. Two point and three point linkage anlaysis among these markers and HLA-A serological types-available for all the studied samples-allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage analysis of genetic disorders mapping on this region of 6p.

KW - Genetic map, linkage analysis, chromosome 6, microsatellites

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DO - 10.1006/mcpr.1993.1060

M3 - Article

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VL - 7

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EP - 414

JO - Molecular and Cellular Probes

JF - Molecular and Cellular Probes

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ER -

Construction of a genetic map telomeric to HLA-A by microsatellite analysis

Abstract

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