Computational modelling approaches to vaccinology

Francesco Pappalardo, Darren Flower, Giulia Russo, Marzio Pennisi, Santo Motta

Risultato della ricerca: Contributo su rivistaArticolo di reviewpeer review

Abstract

Excepting the Peripheral and Central Nervous Systems, the Immune System is the most complex of somatic systems in higher animals. This complexity manifests itself at many levels from the molecular to that of the whole organism. Much insight into this confounding complexity can be gained through computational simulation. Such simulations range in application from epitope prediction through to the modelling of vaccination strategies. In this review, we evaluate selectively various key applications relevant to computational vaccinology: these include technique that operates at different scale that is, from molecular to organisms and even to population level.

Lingua originaleInglese
pagine (da-a)40-45
Numero di pagine6
RivistaPharmacological Research
Volume92
DOI
Stato di pubblicazionePubblicato - feb 2015
Pubblicato esternamente

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