Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins

Aurelia Tubaro; Anna Giangaspero; Silvio Sosa; Roberto Negri; Gianpaolo Grassi; Salvatore Casano; Roberto Della Loggia; Giovanni Appendino

doi:10.1016/j.fitote.2010.04.009

Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins

Aurelia Tubaro, Anna Giangaspero, Silvio Sosa, Roberto Negri, Gianpaolo Grassi, Salvatore Casano, Roberto Della Loggia, Giovanni Appendino

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.

Lingua originale	Inglese
pagine (da-a)	816-819
Numero di pagine	4
Rivista	Fitoterapia
Volume	81
Numero di pubblicazione	7
DOI	https://doi.org/10.1016/j.fitote.2010.04.009
Stato di pubblicazione	Pubblicato - ott 2010
Pubblicato esternamente	Sì

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10.1016/j.fitote.2010.04.009

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title = "Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins",

abstract = "A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.",

keywords = "Anti-inflammatory activity, Cannabinoids, Cannabis sativa L., Cannabivarins, Croton oil assay, Phytocannabinoids",

author = "Aurelia Tubaro and Anna Giangaspero and Silvio Sosa and Roberto Negri and Gianpaolo Grassi and Salvatore Casano and Loggia, {Roberto Della} and Giovanni Appendino",

year = "2010",

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doi = "10.1016/j.fitote.2010.04.009",

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AU - Tubaro, Aurelia

AU - Giangaspero, Anna

AU - Sosa, Silvio

AU - Negri, Roberto

AU - Grassi, Gianpaolo

AU - Casano, Salvatore

AU - Loggia, Roberto Della

AU - Appendino, Giovanni

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N2 - A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.

AB - A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.

KW - Anti-inflammatory activity

KW - Cannabinoids

KW - Cannabis sativa L.

KW - Cannabivarins

KW - Croton oil assay

KW - Phytocannabinoids

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DO - 10.1016/j.fitote.2010.04.009

M3 - Article

SN - 0367-326X

VL - 81

SP - 816

EP - 819

JO - Fitoterapia

JF - Fitoterapia

IS - 7

ER -

Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins

Abstract

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