Comparative Effects of Chronic Haloperidol and Sulpiride Treatment on Nigral and Striatal GABA Content

Ferdinando Nicoletti; Francesco Patti; Daniele Filippo Condorelil; Liborio Rampello; Giovanni Giammona; Rosa‐Maria Di Giorgio; Pier Luigi Canonico; Umberto Scapagnini

doi:10.1111/j.1471-4159.1981.tb04495.x

Comparative Effects of Chronic Haloperidol and Sulpiride Treatment on Nigral and Striatal GABA Content

Ferdinando Nicoletti, Francesco Patti, Daniele Filippo Condorelil, Liborio Rampello, Giovanni Giammona, Rosa‐Maria Di Giorgio, Pier Luigi Canonico, Umberto Scapagnini

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Nigral and striatal GABA contents were assayed in male rats treated chronically with haloperidol or sulpiride, two dopamine‐receptor blocking agents that have different neuropharmacological spectra in regard to their biochemical, behavioural, and clinical properties. No great difference was observed between the chronic effects of haloperidol and sulpiride on nigral and striatal GABA content. However, low doses (30 μg/kg, intraperitoneally) of the dopamine‐receptor agonist apomorphine, injected 12 h after the discontinuation of chronic haloperidol or chronic sulpiride treatment, induced opposite changes in nigral GABA levels suggesting the existence of a different “status” of the dopamine receptors during the 12 h‐period following the withdrawal of haloperidol or sulpiride.

Lingua originale	Inglese
pagine (da-a)	1048-1051
Numero di pagine	4
Rivista	Journal of Neurochemistry
Volume	37
Numero di pubblicazione	4
DOI	https://doi.org/10.1111/j.1471-4159.1981.tb04495.x
Stato di pubblicazione	Pubblicato - ott 1981
Pubblicato esternamente	Sì

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10.1111/j.1471-4159.1981.tb04495.x

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title = "Comparative Effects of Chronic Haloperidol and Sulpiride Treatment on Nigral and Striatal GABA Content",

abstract = "Nigral and striatal GABA contents were assayed in male rats treated chronically with haloperidol or sulpiride, two dopamine‐receptor blocking agents that have different neuropharmacological spectra in regard to their biochemical, behavioural, and clinical properties. No great difference was observed between the chronic effects of haloperidol and sulpiride on nigral and striatal GABA content. However, low doses (30 μg/kg, intraperitoneally) of the dopamine‐receptor agonist apomorphine, injected 12 h after the discontinuation of chronic haloperidol or chronic sulpiride treatment, induced opposite changes in nigral GABA levels suggesting the existence of a different “status” of the dopamine receptors during the 12 h‐period following the withdrawal of haloperidol or sulpiride.",

keywords = "Apomorphine, Corpus Striatum, GABA, Haloperidol, Substantia nigra, Sulpiride",

author = "Ferdinando Nicoletti and Francesco Patti and Condorelil, {Daniele Filippo} and Liborio Rampello and Giovanni Giammona and Giorgio, {Rosa‐Maria Di} and Canonico, {Pier Luigi} and Umberto Scapagnini",

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doi = "10.1111/j.1471-4159.1981.tb04495.x",

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AU - Nicoletti, Ferdinando

AU - Patti, Francesco

AU - Condorelil, Daniele Filippo

AU - Rampello, Liborio

AU - Giammona, Giovanni

AU - Giorgio, Rosa‐Maria Di

AU - Canonico, Pier Luigi

AU - Scapagnini, Umberto

PY - 1981/10

Y1 - 1981/10

N2 - Nigral and striatal GABA contents were assayed in male rats treated chronically with haloperidol or sulpiride, two dopamine‐receptor blocking agents that have different neuropharmacological spectra in regard to their biochemical, behavioural, and clinical properties. No great difference was observed between the chronic effects of haloperidol and sulpiride on nigral and striatal GABA content. However, low doses (30 μg/kg, intraperitoneally) of the dopamine‐receptor agonist apomorphine, injected 12 h after the discontinuation of chronic haloperidol or chronic sulpiride treatment, induced opposite changes in nigral GABA levels suggesting the existence of a different “status” of the dopamine receptors during the 12 h‐period following the withdrawal of haloperidol or sulpiride.

AB - Nigral and striatal GABA contents were assayed in male rats treated chronically with haloperidol or sulpiride, two dopamine‐receptor blocking agents that have different neuropharmacological spectra in regard to their biochemical, behavioural, and clinical properties. No great difference was observed between the chronic effects of haloperidol and sulpiride on nigral and striatal GABA content. However, low doses (30 μg/kg, intraperitoneally) of the dopamine‐receptor agonist apomorphine, injected 12 h after the discontinuation of chronic haloperidol or chronic sulpiride treatment, induced opposite changes in nigral GABA levels suggesting the existence of a different “status” of the dopamine receptors during the 12 h‐period following the withdrawal of haloperidol or sulpiride.

KW - Apomorphine

KW - Corpus Striatum

KW - GABA

KW - Haloperidol

KW - Substantia nigra

KW - Sulpiride

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JO - Journal of Neurochemistry

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ER -

Comparative Effects of Chronic Haloperidol and Sulpiride Treatment on Nigral and Striatal GABA Content

Abstract

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