Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)

Francesca Polverino; Debra A Stern; Gaetano Ruocco; Elisabetta Balestro; Matteo Bassetti; Marcello Candelli; Bruno Cirillo; Marco Contoli; Angelo Corsico; Filippo D'Amico; Emilia D'Elia; Giuseppe Falco; Stefano Gasparini; Stefano Guerra; Sergio Harari; Monica Kraft; Luigi Mennella; Alberto Papi; Roberto Parrella; Paolo Pelosi; Venerino Poletti; Mario Polverino; Claudio Tana; Roberta Terribile; Jason C Woods; Fabiano Di Marco; Fernando D Martinez; ItaliCO study group: F Polverino; D Stern; M Polverino; F D'Amico; E D'Elia; A Agarossi; S Agati; E Agosteo; F Ando'; M Andreoni; I F Angelillo; G Arcoleo; C Arena; P Baiamonte; E Balestro; L Ball; P Banfi; G Bartoletti; R Bartolotta; M Bassetti; D Battaglini; Mattia BELLAN; I Benzoni; R Bertolini; M Bevilacqua; M Bezzi; A Bianco; A Bisbano; F Bobbio; G Bocchialini; F Bonetti; F Boni; M Bonifazi; G Borgonovo; S Borre'; M Bosio; G Brachini; I Brunetti; L Calagna; F Calò; M Candelli; A Capuozzo; T Carr; A Castellani; F Catalano; G Catania; E Catena; M Cattaneo; A Cattelan; V Ceruti; F Chiumiento; G Cicchitto; B Cirillo; M Confalonieri; P Confalonieri; M Contoli; N Coppola; A Corsico; R Cosentina; R Costantino; C Crimi; A Currà; M D'Abbraccio; A Dalbeni; F Daleffe; R Davide; M Del Donno; F Di Marco; F Di Pastena; F Di Perna; Z Di Rosa; A Di Sabatino; O Elesbani; D Elia; V Esposito; L Fabiani; G Falco; G Falo; C Fanelli; A Fantin; F Ferrigno; G Fiorentino; F Franceschi; M Fronza; G Gardini Gardenghi; S Gasparini; D R Giacobbe; C Giannotti; G Giannotti; A Gidari; F Giovanardi; P Gnerre; F Gonnelli; M Graziano; S Greco; A Grosso; S Guarino; S Guerra; S Harari; A Iannarelli; P Imitazione; F Inglese; V Iodice; A Izzo; C La Greca; M Kraft; A Lax; F Legittimo; A Leo; S Leone; V Lepidini; M Leto; F Licata; F Locati; L Lorini; B Lucchetti; I Maida; M Macera; E Manzillo; A March; D Mascheroni; A Mastroianni; I Mauro; M Mazzitelli; E Mazzuca; L Mennella; C Micheletto; A Mingoli; P Minuz; M Moioli; L Monti; R Morgagni; L Mucci; M Muselli; S Negri; C G A Nobile; S Oldani; C Olivieri; A Papi; G Parati; L Parodi; R Parrella; E Pastorelli; V Patruno; F Pellegrino; P Pelosi; M F Pengo; D Pepe; A Perotti; R Petrino; M Petrucci; R M Piane; G Pignataro; M Pino; Mario PIRISI; V Poletti; F Porru; F Pugliese; R Punzi; D A Ramaroli; C Robba; R Rostagno; G Ruocco; U Sabatini; Pier Paolo SAINAGHI; F Salton; C Salzano; A Sanduzzi; S Sanduzzi Zamparelli; V Sangiovanni; D Santopuoli; P Sapienza; L Sarmati; E Schiaroli; F Scienza; M Senni; L Serchisu; S Sgherzi; D Soddu; D Soranna; C Sorino; S Spadaro; E Stirpe; C Tana; S Tardivo; S Tartaglia; E Teopompi; R Terribile; M Tomchaney; E Torelli; C Torlasco; C Torti; E Tupputi; C Ugolinelli; A Vatrella; A G Versace; M Villani; L Vincenzo; C A Volta; N Voraphani; J C Woods; E Zekaj; R Zoppellari; F D Martinez

doi:10.3389/fcvm.2020.585866

Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)

Francesca Polverino, Debra A Stern, Gaetano Ruocco, Elisabetta Balestro, Matteo Bassetti, Marcello Candelli, Bruno Cirillo, Marco Contoli, Angelo Corsico, Filippo D'Amico, Emilia D'Elia, Giuseppe Falco, Stefano Gasparini, Stefano Guerra, Sergio Harari, Monica Kraft, Luigi Mennella, Alberto Papi, Roberto Parrella, Paolo PelosiVenerino Poletti, Mario Polverino, Claudio Tana, Roberta Terribile, Jason C Woods, Fabiano Di Marco, Fernando D Martinez, ItaliCO study group: F Polverino, D Stern, M Polverino, F D'Amico, E D'Elia, A Agarossi, S Agati, E Agosteo, F Ando', M Andreoni, I F Angelillo, G Arcoleo, C Arena, P Baiamonte, E Balestro, L Ball, P Banfi, G Bartoletti, R Bartolotta, M Bassetti, D Battaglini, Mattia BELLAN, I Benzoni, R Bertolini, M Bevilacqua, M Bezzi, A Bianco, A Bisbano, F Bobbio, G Bocchialini, F Bonetti, F Boni, M Bonifazi, G Borgonovo, S Borre', M Bosio, G Brachini, I Brunetti, L Calagna, F Calò, M Candelli, A Capuozzo, T Carr, A Castellani, F Catalano, G Catania, E Catena, M Cattaneo, A Cattelan, V Ceruti, F Chiumiento, G Cicchitto, B Cirillo, M Confalonieri, P Confalonieri, M Contoli, N Coppola, A Corsico, R Cosentina, R Costantino, C Crimi, A Currà, M D'Abbraccio, A Dalbeni, F Daleffe, R Davide, M Del Donno, F Di Marco, F Di Pastena, F Di Perna, Z Di Rosa, A Di Sabatino, O Elesbani, D Elia, V Esposito, L Fabiani, G Falco, G Falo, C Fanelli, A Fantin, F Ferrigno, G Fiorentino, F Franceschi, M Fronza, G Gardini Gardenghi, S Gasparini, D R Giacobbe, C Giannotti, G Giannotti, A Gidari, F Giovanardi, P Gnerre, F Gonnelli, M Graziano, S Greco, A Grosso, S Guarino, S Guerra, S Harari, A Iannarelli, P Imitazione, F Inglese, V Iodice, A Izzo, C La Greca, M Kraft, A Lax, F Legittimo, A Leo, S Leone, V Lepidini, M Leto, F Licata, F Locati, L Lorini, B Lucchetti, I Maida, M Macera, E Manzillo, A March, D Mascheroni, A Mastroianni, I Mauro, M Mazzitelli, E Mazzuca, L Mennella, C Micheletto, A Mingoli, P Minuz, M Moioli, L Monti, R Morgagni, L Mucci, M Muselli, S Negri, C G A Nobile, S Oldani, C Olivieri, A Papi, G Parati, L Parodi, R Parrella, E Pastorelli, V Patruno, F Pellegrino, P Pelosi, M F Pengo, D Pepe, A Perotti, R Petrino, M Petrucci, R M Piane, G Pignataro, M Pino, Mario PIRISI, V Poletti, F Porru, F Pugliese, R Punzi, D A Ramaroli, C Robba, R Rostagno, G Ruocco, U Sabatini, Pier Paolo SAINAGHI, F Salton, C Salzano, A Sanduzzi, S Sanduzzi Zamparelli, V Sangiovanni, D Santopuoli, P Sapienza, L Sarmati, E Schiaroli, F Scienza, M Senni, L Serchisu, S Sgherzi, D Soddu, D Soranna, C Sorino, S Spadaro, E Stirpe, C Tana, S Tardivo, S Tartaglia, E Teopompi, R Terribile, M Tomchaney, E Torelli, C Torlasco, C Torti, E Tupputi, C Ugolinelli, A Vatrella, A G Versace, M Villani, L Vincenzo, C A Volta, N Voraphani, J C Woods, E Zekaj, R Zoppellari, F D Martinez

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: Italy has one of the world's oldest populations, and suffered one the highest death tolls from Coronavirus disease 2019 (COVID-19) worldwide. Older people with cardiovascular diseases (CVDs), and in particular hypertension, are at higher risk of hospitalization and death for COVID-19. Whether hypertension medications may increase the risk for death in older COVID 19 inpatients at the highest risk for the disease is currently unknown.Methods: Data from 5,625 COVID-19 inpatients were manually extracted from medical charts from 61 hospitals across Italy. From the initial 5,625 patients, 3,179 were included in the study as they were either discharged or deceased at the time of the data analysis. Primary outcome was inpatient death or recovery. Mixed effects logistic regression models were adjusted for sex, age, and number of comorbidities, with a random effect for site.Results: A large proportion of participating inpatients were >= 65 years old (58%), male (68%), non-smokers (93%) with comorbidities (66%). Each additional comorbidity increased the risk of death by 35% [adjOR = 1.35 (1.2, 1.5) p < 0.001]. Use of ACE inhibitors, ARBs, beta-blockers or Ca-antagonists was not associated with significantly increased risk of death. There was a marginal negative association between ARB use and death, and a marginal positive association between diuretic use and death.Conclusions: This Italian nationwide observational study of COVID-19 inpatients, the majority of which >= 65 years old, indicates that there is a linear direct relationship between the number of comorbidities and the risk of death. Among CVDs, hypertension and pre-existing cardiomyopathy were significantly associated with risk of death. The use of hypertension medications reported to be safe in younger cohorts, do not contribute significantly to increased COVID-19 related deaths in an older population that suffered one of the highest death tolls worldwide.

Lingua originale	Inglese
pagine (da-a)	585866
Rivista	Frontiers in Cardiovascular Medicine
Volume	7
DOI	https://doi.org/10.3389/fcvm.2020.585866
Stato di pubblicazione	Pubblicato - 2020

Keywords

ACE inhibitors
COVID-19
cohort study
comorbidities
mortality

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Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.3389/fcvm.2020.585866

http://hdl.handle.net/11579/120832

Altri file e collegamenti

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Polverino, F., Stern, D. A., Ruocco, G., Balestro, E., Bassetti, M., Candelli, M., Cirillo, B., Contoli, M., Corsico, A., D'Amico, F., D'Elia, E., Falco, G., Gasparini, S., Guerra, S., Harari, S., Kraft, M., Mennella, L., Papi, A., Parrella, R., ... Martinez, F. D. (2020). Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO). Frontiers in Cardiovascular Medicine, 7, 585866. https://doi.org/10.3389/fcvm.2020.585866

@article{28c45d301d1e4a728428278995b7b8f8,

title = "Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)",

abstract = "Background: Italy has one of the world's oldest populations, and suffered one the highest death tolls from Coronavirus disease 2019 (COVID-19) worldwide. Older people with cardiovascular diseases (CVDs), and in particular hypertension, are at higher risk of hospitalization and death for COVID-19. Whether hypertension medications may increase the risk for death in older COVID 19 inpatients at the highest risk for the disease is currently unknown.Methods: Data from 5,625 COVID-19 inpatients were manually extracted from medical charts from 61 hospitals across Italy. From the initial 5,625 patients, 3,179 were included in the study as they were either discharged or deceased at the time of the data analysis. Primary outcome was inpatient death or recovery. Mixed effects logistic regression models were adjusted for sex, age, and number of comorbidities, with a random effect for site.Results: A large proportion of participating inpatients were >= 65 years old (58%), male (68%), non-smokers (93%) with comorbidities (66%). Each additional comorbidity increased the risk of death by 35% [adjOR = 1.35 (1.2, 1.5) p < 0.001]. Use of ACE inhibitors, ARBs, beta-blockers or Ca-antagonists was not associated with significantly increased risk of death. There was a marginal negative association between ARB use and death, and a marginal positive association between diuretic use and death.Conclusions: This Italian nationwide observational study of COVID-19 inpatients, the majority of which >= 65 years old, indicates that there is a linear direct relationship between the number of comorbidities and the risk of death. Among CVDs, hypertension and pre-existing cardiomyopathy were significantly associated with risk of death. The use of hypertension medications reported to be safe in younger cohorts, do not contribute significantly to increased COVID-19 related deaths in an older population that suffered one of the highest death tolls worldwide.",

keywords = "ACE inhibitors, COVID-19, cohort study, comorbidities, mortality, ACE inhibitors, COVID-19, cohort study, comorbidities, mortality",

author = "Francesca Polverino and Stern, {Debra A} and Gaetano Ruocco and Elisabetta Balestro and Matteo Bassetti and Marcello Candelli and Bruno Cirillo and Marco Contoli and Angelo Corsico and Filippo D'Amico and Emilia D'Elia and Giuseppe Falco and Stefano Gasparini and Stefano Guerra and Sergio Harari and Monica Kraft and Luigi Mennella and Alberto Papi and Roberto Parrella and Paolo Pelosi and Venerino Poletti and Mario Polverino and Claudio Tana and Roberta Terribile and Woods, {Jason C} and {Di Marco}, Fabiano and Martinez, {Fernando D} and Polverino, {ItaliCO study group: F} and D Stern and M Polverino and F D'Amico and E D'Elia and A Agarossi and S Agati and E Agosteo and F Ando' and M Andreoni and Angelillo, {I F} and G Arcoleo and C Arena and P Baiamonte and E Balestro and L Ball and P Banfi and G Bartoletti and R Bartolotta and M Bassetti and D Battaglini and Mattia BELLAN and I Benzoni and R Bertolini and M Bevilacqua and M Bezzi and A Bianco and A Bisbano and F Bobbio and G Bocchialini and F Bonetti and F Boni and M Bonifazi and G Borgonovo and S Borre' and M Bosio and G Brachini and I Brunetti and L Calagna and F Cal{\`o} and M Candelli and A Capuozzo and T Carr and A Castellani and F Catalano and G Catania and E Catena and M Cattaneo and A Cattelan and V Ceruti and F Chiumiento and G Cicchitto and B Cirillo and M Confalonieri and P Confalonieri and M Contoli and N Coppola and A Corsico and R Cosentina and R Costantino and C Crimi and A Curr{\`a} and M D'Abbraccio and A Dalbeni and F Daleffe and R Davide and Donno, {M Del} and Marco, {F Di} and Pastena, {F Di} and Perna, {F Di} and Rosa, {Z Di} and Sabatino, {A Di} and O Elesbani and D Elia and V Esposito and L Fabiani and G Falco and G Falo and C Fanelli and A Fantin and F Ferrigno and G Fiorentino and F Franceschi and M Fronza and Gardenghi, {G Gardini} and S Gasparini and Giacobbe, {D R} and C Giannotti and G Giannotti and A Gidari and F Giovanardi and P Gnerre and F Gonnelli and M Graziano and S Greco and A Grosso and S Guarino and S Guerra and S Harari and A Iannarelli and P Imitazione and F Inglese and V Iodice and A Izzo and Greca, {C La} and M Kraft and A Lax and F Legittimo and A Leo and S Leone and V Lepidini and M Leto and F Licata and F Locati and L Lorini and B Lucchetti and I Maida and M Macera and E Manzillo and A March and D Mascheroni and A Mastroianni and I Mauro and M Mazzitelli and E Mazzuca and L Mennella and C Micheletto and A Mingoli and P Minuz and M Moioli and L Monti and R Morgagni and L Mucci and M Muselli and S Negri and Nobile, {C G A} and S Oldani and C Olivieri and A Papi and G Parati and L Parodi and R Parrella and E Pastorelli and V Patruno and F Pellegrino and P Pelosi and Pengo, {M F} and D Pepe and A Perotti and R Petrino and M Petrucci and Piane, {R M} and G Pignataro and M Pino and Mario PIRISI and V Poletti and F Porru and F Pugliese and R Punzi and Ramaroli, {D A} and C Robba and R Rostagno and G Ruocco and U Sabatini and SAINAGHI, {Pier Paolo} and F Salton and C Salzano and A Sanduzzi and Zamparelli, {S Sanduzzi} and V Sangiovanni and D Santopuoli and P Sapienza and L Sarmati and E Schiaroli and F Scienza and M Senni and L Serchisu and S Sgherzi and D Soddu and D Soranna and C Sorino and S Spadaro and E Stirpe and C Tana and S Tardivo and S Tartaglia and E Teopompi and R Terribile and M Tomchaney and E Torelli and C Torlasco and C Torti and E Tupputi and C Ugolinelli and A Vatrella and Versace, {A G} and M Villani and L Vincenzo and Volta, {C A} and N Voraphani and Woods, {J C} and E Zekaj and R Zoppellari and Martinez, {F D}",

note = "Publisher Copyright: {\textcopyright} 2020 Polverino, Stern, Ruocco, Balestro, Bassetti, Candelli, Cirillo, Contoli, Corsico, D{\textquoteright}Amico, D{\textquoteright}Elia, Falco, Gasparini, Guerra, Harari, Kraft, Mennella, Papi, Parrella, Pelosi, Poletti, Polverino, Tana, Terribile, Woods, Di Marco, Martinez and the ItaliCO study group.",

year = "2020",

doi = "10.3389/fcvm.2020.585866",

language = "English",

volume = "7",

pages = "585866",

journal = "Frontiers in Cardiovascular Medicine",

issn = "2297-055X",

publisher = "Frontiers Media S.A.",

}

Polverino, F, Stern, DA, Ruocco, G, Balestro, E, Bassetti, M, Candelli, M, Cirillo, B, Contoli, M, Corsico, A, D'Amico, F, D'Elia, E, Falco, G, Gasparini, S, Guerra, S, Harari, S, Kraft, M, Mennella, L, Papi, A, Parrella, R, Pelosi, P, Poletti, V, Polverino, M, Tana, C, Terribile, R, Woods, JC, Di Marco, F, Martinez, FD, Polverino, IOSGF, Stern, D, Polverino, M, D'Amico, F, D'Elia, E, Agarossi, A, Agati, S, Agosteo, E, Ando', F, Andreoni, M, Angelillo, IF, Arcoleo, G, Arena, C, Baiamonte, P, Balestro, E, Ball, L, Banfi, P, Bartoletti, G, Bartolotta, R, Bassetti, M, Battaglini, D, BELLAN, M, Benzoni, I, Bertolini, R, Bevilacqua, M, Bezzi, M, Bianco, A, Bisbano, A, Bobbio, F, Bocchialini, G, Bonetti, F, Boni, F, Bonifazi, M, Borgonovo, G, Borre', S, Bosio, M, Brachini, G, Brunetti, I, Calagna, L, Calò, F, Candelli, M, Capuozzo, A, Carr, T, Castellani, A, Catalano, F, Catania, G, Catena, E, Cattaneo, M, Cattelan, A, Ceruti, V, Chiumiento, F, Cicchitto, G, Cirillo, B, Confalonieri, M, Confalonieri, P, Contoli, M, Coppola, N, Corsico, A, Cosentina, R, Costantino, R, Crimi, C, Currà, A, D'Abbraccio, M, Dalbeni, A, Daleffe, F, Davide, R, Donno, MD, Marco, FD, Pastena, FD, Perna, FD, Rosa, ZD, Sabatino, AD, Elesbani, O, Elia, D, Esposito, V, Fabiani, L, Falco, G, Falo, G, Fanelli, C, Fantin, A, Ferrigno, F, Fiorentino, G, Franceschi, F, Fronza, M, Gardenghi, GG, Gasparini, S, Giacobbe, DR, Giannotti, C, Giannotti, G, Gidari, A, Giovanardi, F, Gnerre, P, Gonnelli, F, Graziano, M, Greco, S, Grosso, A, Guarino, S, Guerra, S, Harari, S, Iannarelli, A, Imitazione, P, Inglese, F, Iodice, V, Izzo, A, Greca, CL, Kraft, M, Lax, A, Legittimo, F, Leo, A, Leone, S, Lepidini, V, Leto, M, Licata, F, Locati, F, Lorini, L, Lucchetti, B, Maida, I, Macera, M, Manzillo, E, March, A, Mascheroni, D, Mastroianni, A, Mauro, I, Mazzitelli, M, Mazzuca, E, Mennella, L, Micheletto, C, Mingoli, A, Minuz, P, Moioli, M, Monti, L, Morgagni, R, Mucci, L, Muselli, M, Negri, S, Nobile, CGA, Oldani, S, Olivieri, C, Papi, A, Parati, G, Parodi, L, Parrella, R, Pastorelli, E, Patruno, V, Pellegrino, F, Pelosi, P, Pengo, MF, Pepe, D, Perotti, A, Petrino, R, Petrucci, M, Piane, RM, Pignataro, G, Pino, M, PIRISI, M, Poletti, V, Porru, F, Pugliese, F, Punzi, R, Ramaroli, DA, Robba, C, Rostagno, R, Ruocco, G, Sabatini, U, SAINAGHI, PP, Salton, F, Salzano, C, Sanduzzi, A, Zamparelli, SS, Sangiovanni, V, Santopuoli, D, Sapienza, P, Sarmati, L, Schiaroli, E, Scienza, F, Senni, M, Serchisu, L, Sgherzi, S, Soddu, D, Soranna, D, Sorino, C, Spadaro, S, Stirpe, E, Tana, C, Tardivo, S, Tartaglia, S, Teopompi, E, Terribile, R, Tomchaney, M, Torelli, E, Torlasco, C, Torti, C, Tupputi, E, Ugolinelli, C, Vatrella, A, Versace, AG, Villani, M, Vincenzo, L, Volta, CA, Voraphani, N, Woods, JC, Zekaj, E, Zoppellari, R & Martinez, FD 2020, 'Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)', Frontiers in Cardiovascular Medicine, vol. 7, pagg. 585866. https://doi.org/10.3389/fcvm.2020.585866

TY - JOUR

T1 - Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)

AU - Polverino, Francesca

AU - Stern, Debra A

AU - Ruocco, Gaetano

AU - Balestro, Elisabetta

AU - Bassetti, Matteo

AU - Candelli, Marcello

AU - Cirillo, Bruno

AU - Contoli, Marco

AU - Corsico, Angelo

AU - D'Amico, Filippo

AU - D'Elia, Emilia

AU - Falco, Giuseppe

AU - Gasparini, Stefano

AU - Guerra, Stefano

AU - Harari, Sergio

AU - Kraft, Monica

AU - Mennella, Luigi

AU - Papi, Alberto

AU - Parrella, Roberto

AU - Pelosi, Paolo

AU - Poletti, Venerino

AU - Polverino, Mario

AU - Tana, Claudio

AU - Terribile, Roberta

AU - Woods, Jason C

AU - Di Marco, Fabiano

AU - Martinez, Fernando D

AU - Polverino, ItaliCO study group: F

AU - Stern, D

AU - Polverino, M

AU - D'Amico, F

AU - D'Elia, E

AU - Agarossi, A

AU - Agati, S

AU - Agosteo, E

AU - Ando', F

AU - Andreoni, M

AU - Angelillo, I F

AU - Arcoleo, G

AU - Arena, C

AU - Baiamonte, P

AU - Balestro, E

AU - Ball, L

AU - Banfi, P

AU - Bartoletti, G

AU - Bartolotta, R

AU - Bassetti, M

AU - Battaglini, D

AU - BELLAN, Mattia

AU - Benzoni, I

AU - Bertolini, R

AU - Bevilacqua, M

AU - Bezzi, M

AU - Bianco, A

AU - Bisbano, A

AU - Bobbio, F

AU - Bocchialini, G

AU - Bonetti, F

AU - Boni, F

AU - Bonifazi, M

AU - Borgonovo, G

AU - Borre', S

AU - Bosio, M

AU - Brachini, G

AU - Brunetti, I

AU - Calagna, L

AU - Calò, F

AU - Candelli, M

AU - Capuozzo, A

AU - Carr, T

AU - Castellani, A

AU - Catalano, F

AU - Catania, G

AU - Catena, E

AU - Cattaneo, M

AU - Cattelan, A

AU - Ceruti, V

AU - Chiumiento, F

AU - Cicchitto, G

AU - Cirillo, B

AU - Confalonieri, M

AU - Confalonieri, P

AU - Contoli, M

AU - Coppola, N

AU - Corsico, A

AU - Cosentina, R

AU - Costantino, R

AU - Crimi, C

AU - Currà, A

AU - D'Abbraccio, M

AU - Dalbeni, A

AU - Daleffe, F

AU - Davide, R

AU - Donno, M Del

AU - Marco, F Di

AU - Pastena, F Di

AU - Perna, F Di

AU - Rosa, Z Di

AU - Sabatino, A Di

AU - Elesbani, O

AU - Elia, D

AU - Esposito, V

AU - Fabiani, L

AU - Falco, G

AU - Falo, G

AU - Fanelli, C

AU - Fantin, A

AU - Ferrigno, F

AU - Fiorentino, G

AU - Franceschi, F

AU - Fronza, M

AU - Gardenghi, G Gardini

AU - Gasparini, S

AU - Giacobbe, D R

AU - Giannotti, C

AU - Giannotti, G

AU - Gidari, A

AU - Giovanardi, F

AU - Gnerre, P

AU - Gonnelli, F

AU - Graziano, M

AU - Greco, S

AU - Grosso, A

AU - Guarino, S

AU - Guerra, S

AU - Harari, S

AU - Iannarelli, A

AU - Imitazione, P

AU - Inglese, F

AU - Iodice, V

AU - Izzo, A

AU - Greca, C La

AU - Kraft, M

AU - Lax, A

AU - Legittimo, F

AU - Leo, A

AU - Leone, S

AU - Lepidini, V

AU - Leto, M

AU - Licata, F

AU - Locati, F

AU - Lorini, L

AU - Lucchetti, B

AU - Maida, I

AU - Macera, M

AU - Manzillo, E

AU - March, A

AU - Mascheroni, D

AU - Mastroianni, A

AU - Mauro, I

AU - Mazzitelli, M

AU - Mazzuca, E

AU - Mennella, L

AU - Micheletto, C

AU - Mingoli, A

AU - Minuz, P

AU - Moioli, M

AU - Monti, L

AU - Morgagni, R

AU - Mucci, L

AU - Muselli, M

AU - Negri, S

AU - Nobile, C G A

AU - Oldani, S

AU - Olivieri, C

AU - Papi, A

AU - Parati, G

AU - Parodi, L

AU - Parrella, R

AU - Pastorelli, E

AU - Patruno, V

AU - Pellegrino, F

AU - Pelosi, P

AU - Pengo, M F

AU - Pepe, D

AU - Perotti, A

AU - Petrino, R

AU - Petrucci, M

AU - Piane, R M

AU - Pignataro, G

AU - Pino, M

AU - PIRISI, Mario

AU - Poletti, V

AU - Porru, F

AU - Pugliese, F

AU - Punzi, R

AU - Ramaroli, D A

AU - Robba, C

AU - Rostagno, R

AU - Ruocco, G

AU - Sabatini, U

AU - SAINAGHI, Pier Paolo

AU - Salton, F

AU - Salzano, C

AU - Sanduzzi, A

AU - Zamparelli, S Sanduzzi

AU - Sangiovanni, V

AU - Santopuoli, D

AU - Sapienza, P

AU - Sarmati, L

AU - Schiaroli, E

AU - Scienza, F

AU - Senni, M

AU - Serchisu, L

AU - Sgherzi, S

AU - Soddu, D

AU - Soranna, D

AU - Sorino, C

AU - Spadaro, S

AU - Stirpe, E

AU - Tana, C

AU - Tardivo, S

AU - Tartaglia, S

AU - Teopompi, E

AU - Terribile, R

AU - Tomchaney, M

AU - Torelli, E

AU - Torlasco, C

AU - Torti, C

AU - Tupputi, E

AU - Ugolinelli, C

AU - Vatrella, A

AU - Versace, A G

AU - Villani, M

AU - Vincenzo, L

AU - Volta, C A

AU - Voraphani, N

AU - Woods, J C

AU - Zekaj, E

AU - Zoppellari, R

AU - Martinez, F D

N1 - Publisher Copyright: © 2020 Polverino, Stern, Ruocco, Balestro, Bassetti, Candelli, Cirillo, Contoli, Corsico, D’Amico, D’Elia, Falco, Gasparini, Guerra, Harari, Kraft, Mennella, Papi, Parrella, Pelosi, Poletti, Polverino, Tana, Terribile, Woods, Di Marco, Martinez and the ItaliCO study group.

PY - 2020

Y1 - 2020

N2 - Background: Italy has one of the world's oldest populations, and suffered one the highest death tolls from Coronavirus disease 2019 (COVID-19) worldwide. Older people with cardiovascular diseases (CVDs), and in particular hypertension, are at higher risk of hospitalization and death for COVID-19. Whether hypertension medications may increase the risk for death in older COVID 19 inpatients at the highest risk for the disease is currently unknown.Methods: Data from 5,625 COVID-19 inpatients were manually extracted from medical charts from 61 hospitals across Italy. From the initial 5,625 patients, 3,179 were included in the study as they were either discharged or deceased at the time of the data analysis. Primary outcome was inpatient death or recovery. Mixed effects logistic regression models were adjusted for sex, age, and number of comorbidities, with a random effect for site.Results: A large proportion of participating inpatients were >= 65 years old (58%), male (68%), non-smokers (93%) with comorbidities (66%). Each additional comorbidity increased the risk of death by 35% [adjOR = 1.35 (1.2, 1.5) p < 0.001]. Use of ACE inhibitors, ARBs, beta-blockers or Ca-antagonists was not associated with significantly increased risk of death. There was a marginal negative association between ARB use and death, and a marginal positive association between diuretic use and death.Conclusions: This Italian nationwide observational study of COVID-19 inpatients, the majority of which >= 65 years old, indicates that there is a linear direct relationship between the number of comorbidities and the risk of death. Among CVDs, hypertension and pre-existing cardiomyopathy were significantly associated with risk of death. The use of hypertension medications reported to be safe in younger cohorts, do not contribute significantly to increased COVID-19 related deaths in an older population that suffered one of the highest death tolls worldwide.

AB - Background: Italy has one of the world's oldest populations, and suffered one the highest death tolls from Coronavirus disease 2019 (COVID-19) worldwide. Older people with cardiovascular diseases (CVDs), and in particular hypertension, are at higher risk of hospitalization and death for COVID-19. Whether hypertension medications may increase the risk for death in older COVID 19 inpatients at the highest risk for the disease is currently unknown.Methods: Data from 5,625 COVID-19 inpatients were manually extracted from medical charts from 61 hospitals across Italy. From the initial 5,625 patients, 3,179 were included in the study as they were either discharged or deceased at the time of the data analysis. Primary outcome was inpatient death or recovery. Mixed effects logistic regression models were adjusted for sex, age, and number of comorbidities, with a random effect for site.Results: A large proportion of participating inpatients were >= 65 years old (58%), male (68%), non-smokers (93%) with comorbidities (66%). Each additional comorbidity increased the risk of death by 35% [adjOR = 1.35 (1.2, 1.5) p < 0.001]. Use of ACE inhibitors, ARBs, beta-blockers or Ca-antagonists was not associated with significantly increased risk of death. There was a marginal negative association between ARB use and death, and a marginal positive association between diuretic use and death.Conclusions: This Italian nationwide observational study of COVID-19 inpatients, the majority of which >= 65 years old, indicates that there is a linear direct relationship between the number of comorbidities and the risk of death. Among CVDs, hypertension and pre-existing cardiomyopathy were significantly associated with risk of death. The use of hypertension medications reported to be safe in younger cohorts, do not contribute significantly to increased COVID-19 related deaths in an older population that suffered one of the highest death tolls worldwide.

KW - ACE inhibitors

KW - COVID-19

KW - cohort study

KW - comorbidities

KW - mortality

KW - ACE inhibitors

KW - COVID-19

KW - cohort study

KW - comorbidities

KW - mortality

UR - https://iris.uniupo.it/handle/11579/120832

U2 - 10.3389/fcvm.2020.585866

DO - 10.3389/fcvm.2020.585866

M3 - Article

SN - 2297-055X

VL - 7

SP - 585866

JO - Frontiers in Cardiovascular Medicine

JF - Frontiers in Cardiovascular Medicine

ER -

Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)

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