Collagen-bound α1-microglobulin in normal and healed tissues and its effect on immunocompetent cells

M. Santin, Mario Cannas

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The mechanisms devoted to the protection of the extracellular matrix collagen from the inflammatory insult are not fully understood. We investigated the presence of the immunosuppressive glycoprotein α1- microglobulin in healed tissues such as scars and periprosthetic membranes, comparing them with normal skin. Immunohistochemistry showed that α1- microglobulin was mainly present along collagen fibrils and in the epidermis. The presence of this protein was confirmed by Western blot of the tissue homogenates, while ELISA showed lower levels in the healed tissues. In vitro, the purified α1-microglobulin bound collagen by a cooperative mechanism and attenuated the collagen-induced activation of the mononuclear cells.

Lingua originaleInglese
pagine (da-a)289-295
Numero di pagine7
RivistaScandinavian Journal of Immunology
Volume50
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - 1999
Pubblicato esternamente

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