Clinical relevance of single-subject brain metabolism patterns in amyotrophic lateral sclerosis mutation carriers

Giacomo Tondo, Letizia Mazzini, Silvia Paola Caminiti, Maria Francesca Sarnelli, Lucia CORRADO, Roberta Matheoud, Sandra D'ALFONSO, Roberto CANTELLO, Gian Mauro Sacchetti, Daniela Perani, Cristoforo COMI, Fabiola DE MARCHI

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The ALS diagnosis requires an integrative approach, combining the clinical examination and supporting tests. Nevertheless, in several cases, the diagnosis proves to be suboptimal, and for this reason, new diagnostic methods and novel biomarkers are catching on. The 18F-fluorodeoxyglucose (18F-FDG)-PET could be a helpful method, but it still requires additional research for sensitivity and specificity. We performed an 18F-FDG-PET single-subject analysis in a sample of familial ALS patients carrying different gene mutations, investigating the genotype-phenotype correlations and exploring metabolism correlations with clinical and neuropsychological data.
Lingua originaleInglese
pagine (da-a)103222
RivistaNEUROIMAGE. CLINICAL
Volume36
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • (18)F-FDG-PET
  • Amyotrophic lateral sclerosis
  • Brain metabolism
  • Genetic
  • Neurodegenerative diseases
  • Positron emission tomography

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