TY - JOUR
T1 - Clinical relevance of single-subject brain metabolism patterns in amyotrophic lateral sclerosis mutation carriers
AU - Tondo, Giacomo
AU - Mazzini, Letizia
AU - Caminiti, Silvia Paola
AU - Sarnelli, Maria Francesca
AU - CORRADO, Lucia
AU - Matheoud, Roberta
AU - D'ALFONSO, Sandra
AU - CANTELLO, Roberto
AU - Sacchetti, Gian Mauro
AU - Perani, Daniela
AU - COMI, Cristoforo
AU - DE MARCHI, Fabiola
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022
Y1 - 2022
N2 - The ALS diagnosis requires an integrative approach, combining the clinical examination and supporting tests. Nevertheless, in several cases, the diagnosis proves to be suboptimal, and for this reason, new diagnostic methods and novel biomarkers are catching on. The 18F-fluorodeoxyglucose (18F-FDG)-PET could be a helpful method, but it still requires additional research for sensitivity and specificity. We performed an 18F-FDG-PET single-subject analysis in a sample of familial ALS patients carrying different gene mutations, investigating the genotype-phenotype correlations and exploring metabolism correlations with clinical and neuropsychological data.
AB - The ALS diagnosis requires an integrative approach, combining the clinical examination and supporting tests. Nevertheless, in several cases, the diagnosis proves to be suboptimal, and for this reason, new diagnostic methods and novel biomarkers are catching on. The 18F-fluorodeoxyglucose (18F-FDG)-PET could be a helpful method, but it still requires additional research for sensitivity and specificity. We performed an 18F-FDG-PET single-subject analysis in a sample of familial ALS patients carrying different gene mutations, investigating the genotype-phenotype correlations and exploring metabolism correlations with clinical and neuropsychological data.
KW - (18)F-FDG-PET
KW - Amyotrophic lateral sclerosis
KW - Brain metabolism
KW - Genetic
KW - Neurodegenerative diseases
KW - Positron emission tomography
KW - (18)F-FDG-PET
KW - Amyotrophic lateral sclerosis
KW - Brain metabolism
KW - Genetic
KW - Neurodegenerative diseases
KW - Positron emission tomography
UR - https://iris.uniupo.it/handle/11579/146502
U2 - 10.1016/j.nicl.2022.103222
DO - 10.1016/j.nicl.2022.103222
M3 - Article
SN - 2213-1582
VL - 36
SP - 103222
JO - NEUROIMAGE. CLINICAL
JF - NEUROIMAGE. CLINICAL
ER -