Abstract
The pathogenesis of non-Hodgkin's lymphomas is characterized by distinct genetic lesions which selectively associate with specific NHL clinico-pathological categories. These genetic lesions involve proto-oncogenes (BCL-1/Cyclin D1, BCL-2, BCL-6, c-MYC, NPM/ALK), tumor suppressor genes (p53), and infection of the tumor clone by viral agents (Epstein-Barr virus, Human Herpes virus type-8). The clinical relevance of NHL genetic lesions is three-fold. Firstly, NHL genetic lesions represent highly specific diagnostic tools for the classification of NHL, due to the selective association between a given genetic lesion and a specific NHL clinico-pathological category. Examples are the association between lesions of BCL-1/Cyclin D1 and mantle cell lymphoma, BCL-6 and B-cell diffuse large cell lymphoma, c-MYC and Burkitt's lymphoma, HHV-8 infection and body-cavity-based lymphoma. Secondly, NHL genetic lesions represent independent markers of prognosis for NHL belonging to the same clinicopathological category. Thus, for example, B-cell diffuse large cell lymphomas carrying BCL-6 lesions associate with a favorable outcome in comparison with other genetic variants of B-cell diffuse large cell lymphoma. Finally, NHL genetic lesions may be used as neoplastic markers for the evaluation of minimal residual disease using highly sensitive techniques which allow the detection of lymphoma cells in tissues otherwise scored normal by morphological and immunophenotypic assays.
| Lingua originale | Inglese |
|---|---|
| pagine (da-a) | 187-191 |
| Numero di pagine | 5 |
| Rivista | Cancer Journal |
| Volume | 9 |
| Numero di pubblicazione | 4 |
| Stato di pubblicazione | Pubblicato - 1996 |
| Pubblicato esternamente | Sì |
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