TY - JOUR
T1 - Clinical, histological, and histomorphometric evaluation of demineralized freeze-dried cortical block allografts for alveolar ridge augmentation
AU - Aslan, Elcin
AU - Gultekin, Alper
AU - Karabuda, Cuneyt
AU - Mortellaro, Carmen
AU - Olgac, Vakur
AU - Mijiritsky, Eitan
N1 - Publisher Copyright:
© 2016 by Mutaz B. Habal, MD.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Autogenous bone-block grafts are the "gold standard" for block bone grafting, but have several disadvantages. Allografts have the potential to overcome these disadvantages. The purpose of this study was to evaluate the clinical and histomorphometric features of demineralized freeze-dried cortical block allografts (DCBA) used for ridge augmentation. Eleven patients who showed bone deficiencies of <5mm in the horizontal plane were included in this study. The recipient sites were reconstructed with DCBA. The primary outcomes of interest were bone-width measurements, postoperative clinical evaluations, and histomorphometric analysis of the biopsy samples collected during the implant surgery. Clinical analysis showed that the mean gain in horizontal bone was 1.65±0.14mm, and that the mean percentage of graft resorption was 5.39±2.18%. On postoperative day 7, edema, pain, and bruising were observed in 18.2%, 0%, and 9.1% of the patients, respectively. In the biopsy samples, the mean percentages of newly formed bone, residual block allograft, and marrow and connective tissue were 40.30±24.59%, 40.39±21.36%, and 19.30±15.07%, respectively. All of the block grafts were successfully integrated into the recipient sites. DCBA may be a viable alternative for treating both deficient maxillary and mandibular alveolar ridges.
AB - Autogenous bone-block grafts are the "gold standard" for block bone grafting, but have several disadvantages. Allografts have the potential to overcome these disadvantages. The purpose of this study was to evaluate the clinical and histomorphometric features of demineralized freeze-dried cortical block allografts (DCBA) used for ridge augmentation. Eleven patients who showed bone deficiencies of <5mm in the horizontal plane were included in this study. The recipient sites were reconstructed with DCBA. The primary outcomes of interest were bone-width measurements, postoperative clinical evaluations, and histomorphometric analysis of the biopsy samples collected during the implant surgery. Clinical analysis showed that the mean gain in horizontal bone was 1.65±0.14mm, and that the mean percentage of graft resorption was 5.39±2.18%. On postoperative day 7, edema, pain, and bruising were observed in 18.2%, 0%, and 9.1% of the patients, respectively. In the biopsy samples, the mean percentages of newly formed bone, residual block allograft, and marrow and connective tissue were 40.30±24.59%, 40.39±21.36%, and 19.30±15.07%, respectively. All of the block grafts were successfully integrated into the recipient sites. DCBA may be a viable alternative for treating both deficient maxillary and mandibular alveolar ridges.
KW - Bone augmentation
KW - clinical evaluation
KW - demineralized cortical block allograft
KW - histomorphometric analysis
UR - http://www.scopus.com/inward/record.url?scp=84977120382&partnerID=8YFLogxK
U2 - 10.1097/SCS.0000000000002548
DO - 10.1097/SCS.0000000000002548
M3 - Article
SN - 1049-2275
VL - 27
SP - 1181
EP - 1186
JO - Journal of Craniofacial Surgery
JF - Journal of Craniofacial Surgery
IS - 5
ER -