TY - JOUR
T1 - Clinical features of migraine aura
T2 - Results from a prospective diary-aided study
AU - Viana, Michele
AU - Sances, Grazia
AU - Linde, Mattias
AU - Ghiotto, Natascia
AU - Guaschino, Elena
AU - Allena, Marta
AU - Terrazzino, Salvatore
AU - Nappi, Giuseppe
AU - Goadsby, Peter J.
AU - Tassorelli, Cristina
N1 - Publisher Copyright:
© International Headache Society.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Background A detailed evaluation of migraine aura symptoms is crucial for classification issues and pathophysiological discussion. Few studies have focused on the detailed clinical aspects of migraine aura. Methods We conducted a prospective diary-based study of migraine aura features including presence, quality, laterality, duration of each aura symptom, their temporal succession; presence of headache and its temporal succession with aura. Results Seventy-two patients completed the study recording the characteristics of three consecutive auras (n = 216 auras). Visual symptoms occurred in 212 (98%), sensory symptoms in 77 (36%) and dysphasic symptoms in 22 (10%). Most auras had more than one visual symptom (median 2, IQR 1-3, range 1-4). The majority of patients (56%) did not report a stereotyped aura on the three attacks with respect to visual features, the combination and/or temporal succession of the three aura symptoms. Fifty-seven percent of patients also reported a different scenario of temporal succession between aura and headache in the three attacks. Five per cent of aura symptoms were longer than four hours. Conclusion These findings show a high inter- and intravariability of migraine with aura attacks. Furthermore, they provide reliable data to enrich and clarify the spectrum of the aura phenotype.
AB - Background A detailed evaluation of migraine aura symptoms is crucial for classification issues and pathophysiological discussion. Few studies have focused on the detailed clinical aspects of migraine aura. Methods We conducted a prospective diary-based study of migraine aura features including presence, quality, laterality, duration of each aura symptom, their temporal succession; presence of headache and its temporal succession with aura. Results Seventy-two patients completed the study recording the characteristics of three consecutive auras (n = 216 auras). Visual symptoms occurred in 212 (98%), sensory symptoms in 77 (36%) and dysphasic symptoms in 22 (10%). Most auras had more than one visual symptom (median 2, IQR 1-3, range 1-4). The majority of patients (56%) did not report a stereotyped aura on the three attacks with respect to visual features, the combination and/or temporal succession of the three aura symptoms. Fifty-seven percent of patients also reported a different scenario of temporal succession between aura and headache in the three attacks. Five per cent of aura symptoms were longer than four hours. Conclusion These findings show a high inter- and intravariability of migraine with aura attacks. Furthermore, they provide reliable data to enrich and clarify the spectrum of the aura phenotype.
KW - Migraine with aura
KW - aura symptoms
KW - characteristic
KW - feature
KW - sensory
KW - visual
UR - http://www.scopus.com/inward/record.url?scp=85029009906&partnerID=8YFLogxK
U2 - 10.1177/0333102416657147
DO - 10.1177/0333102416657147
M3 - Article
SN - 0333-1024
VL - 37
SP - 979
EP - 989
JO - Cephalalgia
JF - Cephalalgia
IS - 10
ER -