Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity

Mauro Ravera; Elisabetta Gabano; Ilaria Zanellato; Beatrice Rangone; Elena Perin; Beatrice Ferrari; Maria Grazia Bottone; Domenico Osella

doi:10.1039/d0dt04051g

Cis,cis,trans-[Pt^IVCl₂(NH₃)₂(perillato)₂], a dual-action prodrug with excellent cytotoxic and antimetastatic activity

Mauro Ravera
, Elisabetta Gabano
, Ilaria Zanellato
, Beatrice Rangone
, Elena Perin
, Beatrice Ferrari
, Maria Grazia Bottone
, Domenico Osella

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular,cis,cis,trans-[Pt^IVCl₂(NH₃)₂(perillato)₂] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number ofin vitrobiological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.

Lingua originale	Inglese
pagine (da-a)	3161-3177
Numero di pagine	17
Rivista	Dalton Transactions
Volume	50
Numero di pubblicazione	9
DOI	https://doi.org/10.1039/d0dt04051g
Stato di pubblicazione	Pubblicato - 7 mar 2021

Accesso al documento

10.1039/d0dt04051g

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title = "Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity",

abstract = "Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular,cis,cis,trans-[PtIVCl2(NH3)2(perillato)2] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number ofin vitrobiological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.",

author = "Mauro Ravera and Elisabetta Gabano and Ilaria Zanellato and Beatrice Rangone and Elena Perin and Beatrice Ferrari and Bottone, \{Maria Grazia\} and Domenico Osella",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

year = "2021",

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doi = "10.1039/d0dt04051g",

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TY - JOUR

T1 - Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity

AU - Ravera, Mauro

AU - Gabano, Elisabetta

AU - Zanellato, Ilaria

AU - Rangone, Beatrice

AU - Perin, Elena

AU - Ferrari, Beatrice

AU - Bottone, Maria Grazia

AU - Osella, Domenico

PY - 2021/3/7

Y1 - 2021/3/7

N2 - Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular,cis,cis,trans-[PtIVCl2(NH3)2(perillato)2] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number ofin vitrobiological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.

AB - Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular,cis,cis,trans-[PtIVCl2(NH3)2(perillato)2] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number ofin vitrobiological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.

UR - https://www.scopus.com/pages/publications/85102282866

U2 - 10.1039/d0dt04051g

DO - 10.1039/d0dt04051g

M3 - Article

SN - 1477-9226

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JO - Dalton Transactions

JF - Dalton Transactions

IS - 9