Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

Anouar Fanidi; David C. Muller; Øivind Midttun; Per Magne Ueland; Stein Emil Vollset; Caroline Relton; Paolo Vineis; Elisabete Weiderpass; Guri Skeie; Magritt Brustad; Domenico Palli; Rosario Tumino; Sara Grioni; Carlotta Sacerdote; H. B. Bueno-De-Mesquita; Petra H. Peeters; Marie Christine Boutron-Ruault; Marina Kvaskoff; Claire Cadeau; José María Huerta; Maria José Sánchez; Antonio Agudo; Cristina Lasheras; J. Ramón Quirós; Saioa Chamosa; Elio Riboli; Ruth C. Travis; Heather Ward; Neil Murphy; Kay Tee Khaw; Antonia Trichopoulou; Pagona Lagiou; Eleni Maria Papatesta; Heiner Boeing; Tilman Kuehn; Verena Katzke; Annika Steffen; Anders Johansson; Paul Brennan; Mattias Johansson

doi:10.1038/srep36017

Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

Anouar Fanidi, David C. Muller, Øivind Midttun, Per Magne Ueland, Stein Emil Vollset, Caroline Relton, Paolo Vineis, Elisabete Weiderpass, Guri Skeie, Magritt Brustad, Domenico Palli, Rosario Tumino, Sara Grioni, Carlotta Sacerdote, H. B. Bueno-De-Mesquita, Petra H. Peeters, Marie Christine Boutron-Ruault, Marina Kvaskoff, Claire Cadeau, José María HuertaMaria José Sánchez, Antonio Agudo, Cristina Lasheras, J. Ramón Quirós, Saioa Chamosa, Elio Riboli, Ruth C. Travis, Heather Ward, Neil Murphy, Kay Tee Khaw, Antonia Trichopoulou, Pagona Lagiou, Eleni Maria Papatesta, Heiner Boeing, Tilman Kuehn, Verena Katzke, Annika Steffen, Anders Johansson, Paul Brennan, Mattias Johansson

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D 3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D 3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56-0.88, P trend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39-0.78) and oral cavity cancer (OR 0.60, 95CI% 0.42-0.87). Low 25(OH)D 3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D 3 had decreased risk of HNC, as well as improved survival following diagnosis.

Lingua originale	Inglese
Numero di articolo	36017
Rivista	Scientific Reports
Volume	6
DOI	https://doi.org/10.1038/srep36017
Stato di pubblicazione	Pubblicato - 4 nov 2016
Pubblicato esternamente	Sì

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1038/srep36017

Altri file e collegamenti

Link to publication in Scopus

Cita questo

Fanidi, A., Muller, D. C., Midttun, Ø., Ueland, P. M., Vollset, S. E., Relton, C., Vineis, P., Weiderpass, E., Skeie, G., Brustad, M., Palli, D., Tumino, R., Grioni, S., Sacerdote, C., Bueno-De-Mesquita, H. B., Peeters, P. H., Boutron-Ruault, M. C., Kvaskoff, M., Cadeau, C., ... Johansson, M. (2016). Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Scientific Reports, 6, Articolo 36017. https://doi.org/10.1038/srep36017

@article{99a5fbab1b06465a9b9474b9f34e6307,

title = "Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort",

abstract = "Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D 3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D 3 was associated with 30\% lower odds of HNC (OR 0.70, 95\% confidence interval [95\% CI] 0.56-0.88, P trend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI\% 0.39-0.78) and oral cavity cancer (OR 0.60, 95CI\% 0.42-0.87). Low 25(OH)D 3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D 3 had decreased risk of HNC, as well as improved survival following diagnosis.",

author = "Anouar Fanidi and Muller, \{David C.\} and {\O}ivind Midttun and Ueland, \{Per Magne\} and Vollset, \{Stein Emil\} and Caroline Relton and Paolo Vineis and Elisabete Weiderpass and Guri Skeie and Magritt Brustad and Domenico Palli and Rosario Tumino and Sara Grioni and Carlotta Sacerdote and Bueno-De-Mesquita, \{H. B.\} and Peeters, \{Petra H.\} and Boutron-Ruault, \{Marie Christine\} and Marina Kvaskoff and Claire Cadeau and Huerta, \{Jos{\'e} Mar{\'i}a\} and S{\'a}nchez, \{Maria Jos{\'e}\} and Antonio Agudo and Cristina Lasheras and Quir{\'o}s, \{J. Ram{\'o}n\} and Saioa Chamosa and Elio Riboli and Travis, \{Ruth C.\} and Heather Ward and Neil Murphy and Khaw, \{Kay Tee\} and Antonia Trichopoulou and Pagona Lagiou and Papatesta, \{Eleni Maria\} and Heiner Boeing and Tilman Kuehn and Verena Katzke and Annika Steffen and Anders Johansson and Paul Brennan and Mattias Johansson",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2016.",

year = "2016",

month = nov,

day = "4",

doi = "10.1038/srep36017",

language = "English",

volume = "6",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

Fanidi, A, Muller, DC, Midttun, Ø, Ueland, PM, Vollset, SE, Relton, C, Vineis, P, Weiderpass, E, Skeie, G, Brustad, M, Palli, D, Tumino, R, Grioni, S, Sacerdote, C, Bueno-De-Mesquita, HB, Peeters, PH, Boutron-Ruault, MC, Kvaskoff, M, Cadeau, C, Huerta, JM, Sánchez, MJ, Agudo, A, Lasheras, C, Quirós, JR, Chamosa, S, Riboli, E, Travis, RC, Ward, H, Murphy, N, Khaw, KT, Trichopoulou, A, Lagiou, P, Papatesta, EM, Boeing, H, Kuehn, T, Katzke, V, Steffen, A, Johansson, A, Brennan, P & Johansson, M 2016, 'Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort', Scientific Reports, vol. 6, 36017. https://doi.org/10.1038/srep36017

TY - JOUR

T1 - Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

AU - Fanidi, Anouar

AU - Muller, David C.

AU - Midttun, Øivind

AU - Ueland, Per Magne

AU - Vollset, Stein Emil

AU - Relton, Caroline

AU - Vineis, Paolo

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Brustad, Magritt

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Grioni, Sara

AU - Sacerdote, Carlotta

AU - Bueno-De-Mesquita, H. B.

AU - Peeters, Petra H.

AU - Boutron-Ruault, Marie Christine

AU - Kvaskoff, Marina

AU - Cadeau, Claire

AU - Huerta, José María

AU - Sánchez, Maria José

AU - Agudo, Antonio

AU - Lasheras, Cristina

AU - Quirós, J. Ramón

AU - Chamosa, Saioa

AU - Riboli, Elio

AU - Travis, Ruth C.

AU - Ward, Heather

AU - Murphy, Neil

AU - Khaw, Kay Tee

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Papatesta, Eleni Maria

AU - Boeing, Heiner

AU - Kuehn, Tilman

AU - Katzke, Verena

AU - Steffen, Annika

AU - Johansson, Anders

AU - Brennan, Paul

AU - Johansson, Mattias

PY - 2016/11/4

Y1 - 2016/11/4

N2 - Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D 3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D 3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56-0.88, P trend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39-0.78) and oral cavity cancer (OR 0.60, 95CI% 0.42-0.87). Low 25(OH)D 3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D 3 had decreased risk of HNC, as well as improved survival following diagnosis.

AB - Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D 3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D 3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56-0.88, P trend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39-0.78) and oral cavity cancer (OR 0.60, 95CI% 0.42-0.87). Low 25(OH)D 3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D 3 had decreased risk of HNC, as well as improved survival following diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=84994635746&partnerID=8YFLogxK

U2 - 10.1038/srep36017

DO - 10.1038/srep36017

M3 - Article

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 36017

ER -

Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo