TY - JOUR
T1 - Circulating suPAR levels are affected by glomerular filtration rate and proteinuria in primary and secondary glomerulonephritis
AU - Musetti, Claudio
AU - Quaglia, Marco
AU - Cena, Tiziana
AU - Chiocchetti, Annalisa
AU - Monti, Sara
AU - Clemente, Nausicaa
AU - Magnani, Corrado
AU - Dianzani, Umberto
AU - Stratta, Piero
N1 - Publisher Copyright:
© 2014, Italian Society of Nephrology.
PY - 2015/6/26
Y1 - 2015/6/26
N2 - Background: Circulating levels of soluble urokinase-like plasminogen activator receptor (suPAR) have been associated with proteinuria and renal function in focal segmental glomerulosclerosis (FSGS). This study aimed to evaluate if circulating suPAR levels are independently associated with proteinuria in patients with non-FSGS glomerulonephritis. Methods: This is a cross-sectional analysis of suPAR levels on 42 patients with primary non-FSGS glomerulonephritis (group GN) and 140 patients with secondary glomerulonephritis within an autoimmune disease (group AID). Results: suPAR serum levels were significantly higher in AID patients (4,733 ± 3,073 pg/ml) than in healthy controls (1,908 ± 1,685 pg/ml; p < 0.001), whereas GN patients displayed intermediate levels (3,670 ± 2,435 pg/ml; p = 0.021). Multivariate analysis for elevated serum suPAR (>3,000 pg/ml) showed an independent association with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 [odds ratio (OR) = 4.19, 95 % confidence interval (CI): 1.67–10.54, p = 0.002], proteinuria >0.5 g/day (OR = 2.97; 95 % CI: 1.32–6.70; p = 0.009) and presence of secondary vs. primary GN (OR = 2.87, 95 % CI: 1.25–6.23; p = 0.013). A general linear model confirmed that suPAR levels were significantly affected by proteinuria >0.50 g/day (coefficient +1,477 pg/ml), eGFR (−38 pg/ml per 1 ml/min/1.73 m2 increase) and presence of secondary vs. primary GN (+1,368 pg/ml). Conclusions: This study shows that elevated serum suPAR levels are associated with reduced eGFR and presence of proteinuria in both primary and secondary GN, suggesting that circulating suPAR may represent a common biomarker of renal involvement in a wide spectrum of GN.
AB - Background: Circulating levels of soluble urokinase-like plasminogen activator receptor (suPAR) have been associated with proteinuria and renal function in focal segmental glomerulosclerosis (FSGS). This study aimed to evaluate if circulating suPAR levels are independently associated with proteinuria in patients with non-FSGS glomerulonephritis. Methods: This is a cross-sectional analysis of suPAR levels on 42 patients with primary non-FSGS glomerulonephritis (group GN) and 140 patients with secondary glomerulonephritis within an autoimmune disease (group AID). Results: suPAR serum levels were significantly higher in AID patients (4,733 ± 3,073 pg/ml) than in healthy controls (1,908 ± 1,685 pg/ml; p < 0.001), whereas GN patients displayed intermediate levels (3,670 ± 2,435 pg/ml; p = 0.021). Multivariate analysis for elevated serum suPAR (>3,000 pg/ml) showed an independent association with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 [odds ratio (OR) = 4.19, 95 % confidence interval (CI): 1.67–10.54, p = 0.002], proteinuria >0.5 g/day (OR = 2.97; 95 % CI: 1.32–6.70; p = 0.009) and presence of secondary vs. primary GN (OR = 2.87, 95 % CI: 1.25–6.23; p = 0.013). A general linear model confirmed that suPAR levels were significantly affected by proteinuria >0.50 g/day (coefficient +1,477 pg/ml), eGFR (−38 pg/ml per 1 ml/min/1.73 m2 increase) and presence of secondary vs. primary GN (+1,368 pg/ml). Conclusions: This study shows that elevated serum suPAR levels are associated with reduced eGFR and presence of proteinuria in both primary and secondary GN, suggesting that circulating suPAR may represent a common biomarker of renal involvement in a wide spectrum of GN.
KW - Autoimmunity
KW - Glomerular filtration rate
KW - Primary glomerulonephritis
KW - Proteinuria
KW - Secondary glomerulonephritis
KW - suPAR
UR - http://www.scopus.com/inward/record.url?scp=84924124739&partnerID=8YFLogxK
U2 - 10.1007/s40620-014-0137-1
DO - 10.1007/s40620-014-0137-1
M3 - Article
SN - 1121-8428
VL - 28
SP - 299
EP - 305
JO - Journal of Nephrology
JF - Journal of Nephrology
IS - 3
M1 - 137
ER -