Circulating Peptidome Is Strongly Altered in COVID-19 Patients

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

: Whilst the impact of coronavirus disease 2019 (COVID-19) on the host proteome, metabolome, and lipidome has been largely investigated in different bio-fluids, to date, the circulating peptidome remains unexplored. Thus, the present study aimed to apply an untargeted peptidomic approach to provide insight into alterations of circulating peptides in the development and severity of SARS-CoV-2 infection. The circulating peptidome from COVID-19 severe and mildly symptomatic patients and negative controls was characterized using LC-MS/MS analysis for identification and quantification purposes. Database search and statistical analysis allowed a complete characterization of the plasma peptidome and the detection of the most significant modulated peptides that were impacted by the infection. Our results highlighted not only that peptide abundance inversely correlates with disease severity, but also the involvement of biomolecules belonging to inflammatory, immune-response, and coagulation proteins/processes. Moreover, our data suggested a possible involvement of changes in protein degradation patterns. In the present research, for the first time, the untargeted peptidomic approach enabled the identification of circulating peptides potentially playing a crucial role in the progression of COVID-19.
Lingua originaleInglese
RivistaInternational Journal of Environmental Research and Public Health
Volume20
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • COVID-19
  • biomarkers
  • peptidomics
  • protein degradation
  • respiratory disease

Fingerprint

Entra nei temi di ricerca di 'Circulating Peptidome Is Strongly Altered in COVID-19 Patients'. Insieme formano una fingerprint unica.

Cita questo