TY - JOUR
T1 - Circulating angiopoietin-like protein 2 levels are associated with decreased renal function in HIV + subjects on cART
T2 - A potential marker of kidney disease
AU - Pinzone, Marilia Rita
AU - Ceccarelli, Manuela
AU - Rullo, Emmanuele Venanzi
AU - Maresca, Mauro
AU - Bruno, Roberto
AU - Condorelli, Fabrizio
AU - Di Rosa, Michele
AU - Madeddu, Giordano
AU - Focà, Emanuele
AU - Calcagno, Andrea
AU - Celesia, Benedetto Maurizio
AU - Cacopardo, Bruno
AU - Nunnari, Giuseppe
AU - Pellicanò, Giovanni F.
N1 - Publisher Copyright:
© 2019, Spandidos Publications. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-infected individuals, even in the antiretroviral therapy (ART) era. Inflammatory cytokines and adipokines have been suggested to play a role in the development of CKD. The aim of the present study was to examine the circulating levels of a novel proinflammatory cytokine, angiopoietin-like protein 2 (ANGPTL2), in a cohort of 72 HIV-positive subjects on ART. HIV-positive patients were on cART for at least one year. Urine and blood samples were collected. Various factors were analyzed including body mass index (BMI), smoking, and presence/treatment for comorbidities such as diabetes. The estimated glomerular filtration rate was calculated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Plasma samples obtained were stored and used to measure sCD14 and ANGPTL2 levels. Data were presented as mean (± standard deviation) or median (interquartile range) for continuous variables. Categorical variables were expressed as number (%). Variables were compared using Student's t-test, Mann-Whitney test, or X 2 test. The results showed an independent negative association between plasma ANGPTL2 and CKD-EPI values. Further prospective studies on larger cohorts are needed to evaluate the pathogenetic role of ANGPTL2 as well as its use as a diagnostic marker of renal dysfunction.
AB - Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-infected individuals, even in the antiretroviral therapy (ART) era. Inflammatory cytokines and adipokines have been suggested to play a role in the development of CKD. The aim of the present study was to examine the circulating levels of a novel proinflammatory cytokine, angiopoietin-like protein 2 (ANGPTL2), in a cohort of 72 HIV-positive subjects on ART. HIV-positive patients were on cART for at least one year. Urine and blood samples were collected. Various factors were analyzed including body mass index (BMI), smoking, and presence/treatment for comorbidities such as diabetes. The estimated glomerular filtration rate was calculated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Plasma samples obtained were stored and used to measure sCD14 and ANGPTL2 levels. Data were presented as mean (± standard deviation) or median (interquartile range) for continuous variables. Categorical variables were expressed as number (%). Variables were compared using Student's t-test, Mann-Whitney test, or X 2 test. The results showed an independent negative association between plasma ANGPTL2 and CKD-EPI values. Further prospective studies on larger cohorts are needed to evaluate the pathogenetic role of ANGPTL2 as well as its use as a diagnostic marker of renal dysfunction.
KW - Angiopoietin-like protein 2
KW - CART
KW - CKD-EPI
KW - Inflammation
KW - Renal function
UR - http://www.scopus.com/inward/record.url?scp=85059676792&partnerID=8YFLogxK
U2 - 10.3892/br.2019.1183
DO - 10.3892/br.2019.1183
M3 - Article
SN - 2049-9434
VL - 10
SP - 140
EP - 144
JO - Biomedical Reports
JF - Biomedical Reports
IS - 2
ER -