TY - JOUR
T1 - Chronic alcohol use and first symptomatic epileptic seizures
AU - Leone, M.
AU - Tonini, C.
AU - Bogliun, G.
AU - Monaco, F.
AU - Mutani, R.
AU - Bottacchi, E.
AU - Gambaro, P.
AU - Rocci, E.
AU - Tassinari, T.
AU - Cavestro, C.
AU - Beghi, E.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Objective: To establish whether chronic alcoholism and alcohol consumption are risk factors for developing a first symptomatic epileptic seizure. Methods: Multicentre case-control study of 293 patients (160 men, 133 women) with a first seizure symptomatic (either acute or remote) of head trauma, stroke, or brain tumour, matched to 444 hospital controls for centre, sex, age (±5 years), and underlying pathology. Results: The risk of first seizure in alcoholics was no higher than in non-alcoholics for men (odds ratio 1.2, 95% confidence interval 0.4 to 3.2) or women (1.5, 0.1 to 54.4). The odds ratio (both sexes) was 1.2 (0.8 to 1.7) for an average intake of absolute alcohol of 1-25 g/day, 0.9 (0.5 to 1.5) for 26-50 g/day, 1.6 (0.8 to 3.0) for 51-100 g/day, and 1.4 (0.5 to 3.5) for > 100 g/day. Conclusions: We found no evidence of an association between alcohol use or alcoholism and a first symptomatic seizure.
AB - Objective: To establish whether chronic alcoholism and alcohol consumption are risk factors for developing a first symptomatic epileptic seizure. Methods: Multicentre case-control study of 293 patients (160 men, 133 women) with a first seizure symptomatic (either acute or remote) of head trauma, stroke, or brain tumour, matched to 444 hospital controls for centre, sex, age (±5 years), and underlying pathology. Results: The risk of first seizure in alcoholics was no higher than in non-alcoholics for men (odds ratio 1.2, 95% confidence interval 0.4 to 3.2) or women (1.5, 0.1 to 54.4). The odds ratio (both sexes) was 1.2 (0.8 to 1.7) for an average intake of absolute alcohol of 1-25 g/day, 0.9 (0.5 to 1.5) for 26-50 g/day, 1.6 (0.8 to 3.0) for 51-100 g/day, and 1.4 (0.5 to 3.5) for > 100 g/day. Conclusions: We found no evidence of an association between alcohol use or alcoholism and a first symptomatic seizure.
UR - http://www.scopus.com/inward/record.url?scp=0036829566&partnerID=8YFLogxK
U2 - 10.1136/jnnp.73.5.495
DO - 10.1136/jnnp.73.5.495
M3 - Article
SN - 0022-3050
VL - 73
SP - 495
EP - 499
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 5
ER -