Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Rohini Gomathinayagam; Ji Hee Ha; Muralidharan Jayaraman; Yong Sang Song; Ciro ISIDORO; Danny N Dhanasekaran

doi:10.15430/JCP.2020.25.3.136

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Rohini Gomathinayagam, Ji Hee Ha, Muralidharan Jayaraman, Yong Sang Song, Ciro ISIDORO, Danny N Dhanasekaran

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

Lingua originale	Inglese
pagine (da-a)	136-151-151
Rivista	JOURNAL OF CANCER PREVENTION
Volume	25
Numero di pubblicazione	3
DOI	https://doi.org/10.15430/JCP.2020.25.3.136
Stato di pubblicazione	Pubblicato - 1 gen 2020

Keywords

Antineoplastic agent
Chemoprevention
Neoplasms
Nigella sativa
Thymoquinone

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10.15430/JCP.2020.25.3.136

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abstract = "Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.",

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author = "Rohini Gomathinayagam and Ha, {Ji Hee} and Muralidharan Jayaraman and Song, {Yong Sang} and Ciro ISIDORO and Dhanasekaran, {Danny N}",

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doi = "10.15430/JCP.2020.25.3.136",

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AU - Gomathinayagam, Rohini

AU - Ha, Ji Hee

AU - Jayaraman, Muralidharan

AU - Song, Yong Sang

AU - ISIDORO, Ciro

AU - Dhanasekaran, Danny N

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AB - Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

KW - Antineoplastic agent

KW - Chemoprevention

KW - Neoplasms

KW - Nigella sativa

KW - Thymoquinone

KW - Antineoplastic agent

KW - Chemoprevention

KW - Neoplasms

KW - Nigella sativa

KW - Thymoquinone

UR - https://iris.uniupo.it/handle/11579/119604

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DO - 10.15430/JCP.2020.25.3.136

M3 - Article

SN - 2288-3649

VL - 25

SP - 136-151-151

JO - JOURNAL OF CANCER PREVENTION

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IS - 3

ER -

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Abstract

Keywords

OSS delle Nazioni Unite

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