Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Alberto Mantovani; Paola Allavena; Silvano Sozzani; Annunciata Vecchi; Massimo Locati; Antonio Sica

doi:10.1016/j.semcancer.2003.10.001

Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Alberto Mantovani, Paola Allavena, Silvano Sozzani, Annunciata Vecchi, Massimo Locati, Antonio Sica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

Lingua originale	Inglese
pagine (da-a)	155-160
Numero di pagine	6
Rivista	Seminars in Cancer Biology
Volume	14
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/j.semcancer.2003.10.001
Stato di pubblicazione	Pubblicato - giu 2004
Pubblicato esternamente	Sì

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1016/j.semcancer.2003.10.001

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{6679e8d7b8bf48da94c804d15b0aea21,

title = "Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors",

abstract = "Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.",

keywords = "Chemokines, Infiltrating leukocytes, Recruitment",

author = "Alberto Mantovani and Paola Allavena and Silvano Sozzani and Annunciata Vecchi and Massimo Locati and Antonio Sica",

year = "2004",

month = jun,

doi = "10.1016/j.semcancer.2003.10.001",

language = "English",

volume = "14",

pages = "155--160",

journal = "Seminars in Cancer Biology",

issn = "1044-579X",

publisher = "Academic Press",

number = "3",

}

TY - JOUR

T1 - Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

AU - Mantovani, Alberto

AU - Allavena, Paola

AU - Sozzani, Silvano

AU - Vecchi, Annunciata

AU - Locati, Massimo

AU - Sica, Antonio

PY - 2004/6

Y1 - 2004/6

N2 - Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

AB - Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

KW - Chemokines

KW - Infiltrating leukocytes

KW - Recruitment

UR - http://www.scopus.com/inward/record.url?scp=2342565892&partnerID=8YFLogxK

U2 - 10.1016/j.semcancer.2003.10.001

DO - 10.1016/j.semcancer.2003.10.001

M3 - Article

SN - 1044-579X

VL - 14

SP - 155

EP - 160

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

IS - 3

ER -

Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo