Characterization of anti-coagulant properties of prenylated coumarin ferulenol

Monia Monti; Mirko Pinotti; Giovanni Appendino; Franco Dallocchio; Tiziana Bellini; Fabiana Antognoni; Ferruccio Poli; Francesco Bernardi

doi:10.1016/j.bbagen.2007.06.013

Characterization of anti-coagulant properties of prenylated coumarin ferulenol

Monia Monti, Mirko Pinotti, Giovanni Appendino, Franco Dallocchio, Tiziana Bellini, Fabiana Antognoni, Ferruccio Poli, Francesco Bernardi

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (< 100 nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.

Lingua originale	Inglese
pagine (da-a)	1437-1440
Numero di pagine	4
Rivista	Biochimica et Biophysica Acta - General Subjects
Volume	1770
Numero di pubblicazione	10
DOI	https://doi.org/10.1016/j.bbagen.2007.06.013
Stato di pubblicazione	Pubblicato - ott 2007
Pubblicato esternamente	Sì

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10.1016/j.bbagen.2007.06.013

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title = "Characterization of anti-coagulant properties of prenylated coumarin ferulenol",

abstract = "We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (< 100 nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.",

keywords = "Blood coagulation, Cellular models, Factor X, Ferulenol, Haemorrhagic tendency",

author = "Monia Monti and Mirko Pinotti and Giovanni Appendino and Franco Dallocchio and Tiziana Bellini and Fabiana Antognoni and Ferruccio Poli and Francesco Bernardi",

note = "Funding Information: This work was supported by Grants from Ferrara University (MM, MP, FB, FD, TB), Bologna University (FP, FA) and Piemonte Orientale University (GA). The study was supported by MIUR-COFIN (MM, MP, FB), Telethon (GGP05214) (MP, FB) and Carife (FD, TB).",

year = "2007",

month = oct,

doi = "10.1016/j.bbagen.2007.06.013",

language = "English",

volume = "1770",

pages = "1437--1440",

journal = "Biochimica et Biophysica Acta - General Subjects",

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T1 - Characterization of anti-coagulant properties of prenylated coumarin ferulenol

AU - Monti, Monia

AU - Pinotti, Mirko

AU - Appendino, Giovanni

AU - Dallocchio, Franco

AU - Bellini, Tiziana

AU - Antognoni, Fabiana

AU - Poli, Ferruccio

AU - Bernardi, Francesco

N1 - Funding Information: This work was supported by Grants from Ferrara University (MM, MP, FB, FD, TB), Bologna University (FP, FA) and Piemonte Orientale University (GA). The study was supported by MIUR-COFIN (MM, MP, FB), Telethon (GGP05214) (MP, FB) and Carife (FD, TB).

PY - 2007/10

Y1 - 2007/10

N2 - We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (< 100 nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.

AB - We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (< 100 nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.

KW - Blood coagulation

KW - Cellular models

KW - Factor X

KW - Ferulenol

KW - Haemorrhagic tendency

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U2 - 10.1016/j.bbagen.2007.06.013

DO - 10.1016/j.bbagen.2007.06.013

M3 - Article

SN - 0304-4165

VL - 1770

SP - 1437

EP - 1440

JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

IS - 10

ER -

Characterization of anti-coagulant properties of prenylated coumarin ferulenol

Abstract

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