TY - JOUR
T1 - Chapter 8
T2 - Regulation of gene expression in the olfactory neuroepithelium: A neurogenetic matrix
AU - Margolis, F. L.
AU - Verhaagen, J.
AU - Biffo, S.
AU - Huang, F. L.
AU - Grillo, M.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - The olfactory neuroepithelium exhibits neurogenesis throughout adult life, and in response to lesions, a phenomenon that distinguishes this neural tissue from the rest of the mammalian brain. This chapter reviews studies on the expression of B50/GAP43 during ontogeny of the olfactory system and following lesioning. This analysis includes the characterization of the expression of olfactory marker protein (OMP), a protein expressed in mature olfactory neurons, as well as protein kinase-C and calmodulin. The latter two molecules are of particular interest to the function of B50/GAP43 because the degree of phosphorylation of B50/GAP43 appears to determine B50/GAP43's ability to bind calmodulin. In the mature olfactory epithelium, B50/ GAP-43 expression is restricted to a subset of cells located in the basal region. Because the expression of B50/GAP43 is high in developing and regenerating nerve cells, the B50/GAP43 positive cells are new neurons derived from the stem cells in the basal region of the epithelium. B50/GAP43 is absent from the stem cells themselves and also from the mature OMP-expressing neurons.
AB - The olfactory neuroepithelium exhibits neurogenesis throughout adult life, and in response to lesions, a phenomenon that distinguishes this neural tissue from the rest of the mammalian brain. This chapter reviews studies on the expression of B50/GAP43 during ontogeny of the olfactory system and following lesioning. This analysis includes the characterization of the expression of olfactory marker protein (OMP), a protein expressed in mature olfactory neurons, as well as protein kinase-C and calmodulin. The latter two molecules are of particular interest to the function of B50/GAP43 because the degree of phosphorylation of B50/GAP43 appears to determine B50/GAP43's ability to bind calmodulin. In the mature olfactory epithelium, B50/ GAP-43 expression is restricted to a subset of cells located in the basal region. Because the expression of B50/GAP43 is high in developing and regenerating nerve cells, the B50/GAP43 positive cells are new neurons derived from the stem cells in the basal region of the epithelium. B50/GAP43 is absent from the stem cells themselves and also from the mature OMP-expressing neurons.
UR - http://www.scopus.com/inward/record.url?scp=0026343832&partnerID=8YFLogxK
U2 - 10.1016/S0079-6123(08)61718-5
DO - 10.1016/S0079-6123(08)61718-5
M3 - Article
SN - 0079-6123
VL - 89
SP - 97
EP - 122
JO - Progress in Brain Research
JF - Progress in Brain Research
IS - C
ER -