Changes in bone mineral density, lean body mass and fat content as measured by dual energy x-ray absorptiometry in patients with prostate cancer without apparent bone metastases given androgen deprivation therapy

Alfredo Berruti, Luigi Dogliotti, Carlo Terrone, Stefania Cerutti, Giancarlo Isaia, Roberto Tarabuzzi, Giuseppe Reimondo, Mauro Mari, Paola Ardissone, Stefano De Luca, Giuseppe Fasolis, Dario Fontana, Salvatore Rocca Rossetti, Alberto Angeli

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Purpose: We characterize the consequences of androgen deprivation therapy on body composition in elderly men. Materials and Methods: Using a dual energy x-ray absorptiometry instrument, we determined the changes in bone mineral density, bone mineral content, fat body mass and lean body mass in 35 patients with prostate cancer without bone metastases who received luteinizing hormone releasing hormone analogue for 12 months. Results: At baseline conditions 46% of cases were classified as osteopenic and 14% as osteoporotic at the lumbar spine and 40% were osteopenic and 4% osteoporotic at the hip. Androgen deprivation significantly decreased bone mineral density either at the lumbar spine (mean gm./cm.2 [SD] 1.00 [0.194], 0.986 [0.172] and 0.977 [0.182] at baseline, and 6 and 12 months, respectively, p <0.002) or the hip (0.929 [0.136], 0.926 [0.144] and 0.923 [0.138], p <0.03). A more than 2% decrease in bone mineral density was found at the lumbar spine in 19 men (54.3%) and at the hip in 15 (42.9%). Bone mineral content paralleled the bone mineral density pattern. Lean body mass decreased (mean gm. [SD] 50,287 [6,656], 49,296 [6,554] and 49,327 [6,345], p <0.003), whereas fat body mass consistently increased (18,115 [6,209], 20,724 [6,029] and 21,604 [5,923] p <0.001). Conclusions: Serial bone densitometry evaluation during androgen deprivation therapy may allow the detection of patients with prostate cancer at risk for osteoporotic fractures, that is those with osteopenia or osteoporosis at baseline and fast bone loss. The change in body composition may predispose patients to accidental falls, thus increasing the risk of bone fracture.

Lingua originaleInglese
pagine (da-a)2361-2367
Numero di pagine7
RivistaJournal of Urology
Volume167
Numero di pubblicazione6
DOI
Stato di pubblicazionePubblicato - 2002
Pubblicato esternamente

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