TY - JOUR
T1 - CD45 and multiple sclerosis
T2 - The exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers
AU - Gomez-Lira, Macarena
AU - Liguori, Maria
AU - Magnani, Corrado
AU - Bonamini, Deborah
AU - Salviati, Alessandro
AU - Leone, Maurizio
AU - Andreoli, Virginia
AU - Trojano, Maria
AU - Valentino, Paola
AU - Savettieri, Giovanni
AU - Quattrone, Aldo
AU - Pignatti, Pier Franco
AU - Momigliano-Richiardi, Patricia
AU - Giordano, Mara
PY - 2003/7
Y1 - 2003/7
N2 - We re-evaluated the association with multiple sclerosis (MS) of the C77G splicing regulatory variation in the CD45 gene and screened for new mutations the three alternatively spliced exons (#4, 5 and 6). No association with C77G was detected in two groups of patients (total=448) and controls (total=559) from Northern and Southern Italy. When excluding the first published study indicating a positive association, a meta-analysis of the five further studies conducted to date (including the present one) led to a non-significant combined odds ratio (OR) of 1.11. None of the four newly identified nucleotide substitutions, namely C77T (Pro59Pro) in exon 4, G69C (Asp121His) in exon 5, T127A (Ile187Asn) and A138G (Thr191Ala) in exon 6, was significantly associated to MS.
AB - We re-evaluated the association with multiple sclerosis (MS) of the C77G splicing regulatory variation in the CD45 gene and screened for new mutations the three alternatively spliced exons (#4, 5 and 6). No association with C77G was detected in two groups of patients (total=448) and controls (total=559) from Northern and Southern Italy. When excluding the first published study indicating a positive association, a meta-analysis of the five further studies conducted to date (including the present one) led to a non-significant combined odds ratio (OR) of 1.11. None of the four newly identified nucleotide substitutions, namely C77T (Pro59Pro) in exon 4, G69C (Asp121His) in exon 5, T127A (Ile187Asn) and A138G (Thr191Ala) in exon 6, was significantly associated to MS.
KW - Association study
KW - CD45
KW - Meta-analysis
KW - Multiple sclerosis
UR - https://www.scopus.com/pages/publications/0038642831
U2 - 10.1016/S0165-5728(03)00208-X
DO - 10.1016/S0165-5728(03)00208-X
M3 - Article
SN - 0165-5728
VL - 140
SP - 216
EP - 221
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -