CD38: A multi-lineage cell activation molecule with a split personality

Fabio Malavasi; Ada Funaro; Massimo Alessio; Lucia B. DeMonte; Clara M. Ausiello; Umberto Dianzani; Francesco Lanza; Elisabetta Magrini; Monica Momo; Stefano Roggero

doi:10.1007/BF02591400

CD38: A multi-lineage cell activation molecule with a split personality

Fabio Malavasi, Ada Funaro, Massimo Alessio, Lucia B. DeMonte, Clara M. Ausiello, Umberto Dianzani, Francesco Lanza, Elisabetta Magrini, Monica Momo, Stefano Roggero

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

This review reports the characteristics of the human surface molecule CD38, a structure not linked to a definite line and predominantly expressed in early and activated phenotypes. The CD38 molecule consists of a single chain of 46 kDa, spanning the membrane and with the carboxyl terminus located in the extracellular compartment. The CD38 molecule is also involved in the transduction of activation and proliferation signals, which are line unrestricted. The gene coding for the CD38 antigen has been cloned and used for the construction of simian and mouse transfectants expressing the human molecule. These cell models are used for the analysis of several unanswered issues, mainly concerning the in vivo function of CD38, the existence of a natural ligand and of polymorphism in the population.

Lingua originale	Inglese
pagine (da-a)	73-80
Numero di pagine	8
Rivista	International Journal of Clinical and Laboratory Research
Volume	22
Numero di pubblicazione	1-4
DOI	https://doi.org/10.1007/BF02591400
Stato di pubblicazione	Pubblicato - mar 1992
Pubblicato esternamente	Sì

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10.1007/BF02591400

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title = "CD38: A multi-lineage cell activation molecule with a split personality",

abstract = "This review reports the characteristics of the human surface molecule CD38, a structure not linked to a definite line and predominantly expressed in early and activated phenotypes. The CD38 molecule consists of a single chain of 46 kDa, spanning the membrane and with the carboxyl terminus located in the extracellular compartment. The CD38 molecule is also involved in the transduction of activation and proliferation signals, which are line unrestricted. The gene coding for the CD38 antigen has been cloned and used for the construction of simian and mouse transfectants expressing the human molecule. These cell models are used for the analysis of several unanswered issues, mainly concerning the in vivo function of CD38, the existence of a natural ligand and of polymorphism in the population.",

keywords = "Agonistic antibody, CD38/T10, Cell activation and proliferation, Cluster designation",

author = "Fabio Malavasi and Ada Funaro and Massimo Alessio and DeMonte, \{Lucia B.\} and Ausiello, \{Clara M.\} and Umberto Dianzani and Francesco Lanza and Elisabetta Magrini and Monica Momo and Stefano Roggero",

year = "1992",

month = mar,

doi = "10.1007/BF02591400",

language = "English",

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journal = "International Journal of Clinical and Laboratory Research",

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TY - JOUR

T1 - CD38

T2 - A multi-lineage cell activation molecule with a split personality

AU - Malavasi, Fabio

AU - Funaro, Ada

AU - Alessio, Massimo

AU - DeMonte, Lucia B.

AU - Ausiello, Clara M.

AU - Dianzani, Umberto

AU - Lanza, Francesco

AU - Magrini, Elisabetta

AU - Momo, Monica

AU - Roggero, Stefano

PY - 1992/3

Y1 - 1992/3

N2 - This review reports the characteristics of the human surface molecule CD38, a structure not linked to a definite line and predominantly expressed in early and activated phenotypes. The CD38 molecule consists of a single chain of 46 kDa, spanning the membrane and with the carboxyl terminus located in the extracellular compartment. The CD38 molecule is also involved in the transduction of activation and proliferation signals, which are line unrestricted. The gene coding for the CD38 antigen has been cloned and used for the construction of simian and mouse transfectants expressing the human molecule. These cell models are used for the analysis of several unanswered issues, mainly concerning the in vivo function of CD38, the existence of a natural ligand and of polymorphism in the population.

AB - This review reports the characteristics of the human surface molecule CD38, a structure not linked to a definite line and predominantly expressed in early and activated phenotypes. The CD38 molecule consists of a single chain of 46 kDa, spanning the membrane and with the carboxyl terminus located in the extracellular compartment. The CD38 molecule is also involved in the transduction of activation and proliferation signals, which are line unrestricted. The gene coding for the CD38 antigen has been cloned and used for the construction of simian and mouse transfectants expressing the human molecule. These cell models are used for the analysis of several unanswered issues, mainly concerning the in vivo function of CD38, the existence of a natural ligand and of polymorphism in the population.

KW - Agonistic antibody

KW - CD38/T10

KW - Cell activation and proliferation

KW - Cluster designation

UR - https://www.scopus.com/pages/publications/18344400217

U2 - 10.1007/BF02591400

DO - 10.1007/BF02591400

M3 - Review article

SN - 0940-5437

VL - 22

SP - 73

EP - 80

JO - International Journal of Clinical and Laboratory Research

JF - International Journal of Clinical and Laboratory Research

IS - 1-4

ER -

CD38: A multi-lineage cell activation molecule with a split personality

Abstract

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