Cannabioxepane, a novel tetracyclic cannabinoid from hemp, Cannabis sativa L.

Alberto Pagani, Fernando Scala, Giuseppina Chianese, Gianpaolo Grassi, Giovanni Appendino, Orazio Taglialatela-Scafati

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Apart from large amounts of cannabidiol, the known stilbenoids 1-4 and the oxylipins 7 and 8, a fibre cultivar of Cannabis sativa derived from the historical Carmagnola variety gave the novel spiranic stilbenoid isocannabispiradienone (5) and the biphenyl-type cannabinoid cannabioxepane (CBX, 6), a tetracyclic compound characterized by an unprecedented C-5/C-8′ oxygen bridge and devoid of cannabinoid activity. Structures were established by analysis of MS and NMR data, and the biogenetic derivation of the new compounds is discussed.

Lingua originaleInglese
pagine (da-a)3369-3373
Numero di pagine5
RivistaTetrahedron
Volume67
Numero di pubblicazione19
DOI
Stato di pubblicazionePubblicato - 13 mag 2011
Pubblicato esternamente

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