Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study

Ivan Anchesi; Federica Betto; Luigi Chiricosta; Agnese Gugliandolo; Federica Pollastro; Stefano Salamone; Emanuela Mazzon

doi:10.3390/plants12010193

Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study

Ivan Anchesi
, Federica Betto
, Luigi Chiricosta
, Agnese Gugliandolo
, Federica Pollastro
, Stefano Salamone
, Emanuela Mazzon

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the Cannabis sativa L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance.

Lingua originale	Inglese
Numero di articolo	193
Rivista	Plants
Volume	12
Numero di pubblicazione	1
DOI	https://doi.org/10.3390/plants12010193
Stato di pubblicazione	Pubblicato - gen 2023

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10.3390/plants12010193

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title = "Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study",

abstract = "Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the Cannabis sativa L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance.",

keywords = "Ephrin-Eph signaling, NSC-34, WNT/planar cell polarity (PCP) signaling, axon guidance, cannabigerol",

author = "Ivan Anchesi and Federica Betto and Luigi Chiricosta and Agnese Gugliandolo and Federica Pollastro and Stefano Salamone and Emanuela Mazzon",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jan,

doi = "10.3390/plants12010193",

language = "English",

volume = "12",

journal = "Plants",

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TY - JOUR

T1 - Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34

T2 - An In Vitro Transcriptional Study

AU - Anchesi, Ivan

AU - Betto, Federica

AU - Chiricosta, Luigi

AU - Gugliandolo, Agnese

AU - Pollastro, Federica

AU - Salamone, Stefano

AU - Mazzon, Emanuela

PY - 2023/1

Y1 - 2023/1

N2 - Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the Cannabis sativa L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance.

AB - Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the Cannabis sativa L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance.

KW - Ephrin-Eph signaling

KW - NSC-34

KW - WNT/planar cell polarity (PCP) signaling

KW - axon guidance

KW - cannabigerol

UR - https://www.scopus.com/pages/publications/85145818536

U2 - 10.3390/plants12010193

DO - 10.3390/plants12010193

M3 - Article

SN - 2223-7747

VL - 12

JO - Plants

JF - Plants

IS - 1

M1 - 193

ER -

Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study

Abstract

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