Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability

Francesco Colotta; Paola Allavena; Antonio Sica; Cecilia Garlanda; Alberto Mantovani

doi:10.1093/carcin/bgp127

Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability

Francesco Colotta, Paola Allavena, Antonio Sica, Cecilia Garlanda, Alberto Mantovani

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.

Lingua originale	Inglese
pagine (da-a)	1073-1081
Numero di pagine	9
Rivista	Carcinogenesis
Volume	30
Numero di pubblicazione	7
DOI	https://doi.org/10.1093/carcin/bgp127
Stato di pubblicazione	Pubblicato - 2009

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title = "Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability",

abstract = "Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.",

author = "Francesco Colotta and Paola Allavena and Antonio Sica and Cecilia Garlanda and Alberto Mantovani",

year = "2009",

doi = "10.1093/carcin/bgp127",

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TY - JOUR

T1 - Cancer-related inflammation, the seventh hallmark of cancer

T2 - Links to genetic instability

AU - Colotta, Francesco

AU - Allavena, Paola

AU - Sica, Antonio

AU - Garlanda, Cecilia

AU - Mantovani, Alberto

PY - 2009

Y1 - 2009

N2 - Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.

AB - Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.

UR - https://www.scopus.com/pages/publications/67650151005

U2 - 10.1093/carcin/bgp127

DO - 10.1093/carcin/bgp127

M3 - Review article

SN - 0143-3334

VL - 30

SP - 1073

EP - 1081

JO - Carcinogenesis

JF - Carcinogenesis

IS - 7

ER -

Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability

Abstract

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