Cancer related inflammation: The macrophage connection

Antonio Sica; Paola Allavena; Alberto Mantovani

doi:10.1016/j.canlet.2008.03.028

Cancer related inflammation: The macrophage connection

Antonio Sica, Paola Allavena, Alberto Mantovani

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

Lingua originale	Inglese
pagine (da-a)	204-215
Numero di pagine	12
Rivista	Cancer Letters
Volume	267
Numero di pubblicazione	2
DOI	https://doi.org/10.1016/j.canlet.2008.03.028
Stato di pubblicazione	Pubblicato - 28 ago 2008
Pubblicato esternamente	Sì

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10.1016/j.canlet.2008.03.028

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@article{4bebc46cf31a4861be4275f3c4d01973,

title = "Cancer related inflammation: The macrophage connection",

abstract = "Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.",

keywords = "Angiogenesis, Cancer, Chemokines, Cytokines, Inflammation, Macrophage polarization, Therapeutic targets, Tumor promotion, Tumor-associated macrophages",

author = "Antonio Sica and Paola Allavena and Alberto Mantovani",

note = "Funding Information: This work was supported by Associazione Italiana Ricerca sul Cancro (AIRC), Italy; European Community and Ministero Istruzione Universit{\`a} Ricerca (MIUR), Italy; Istituto Superiore Sanita{\textquoteright} (ISS).",

year = "2008",

month = aug,

day = "28",

doi = "10.1016/j.canlet.2008.03.028",

language = "English",

volume = "267",

pages = "204--215",

journal = "Cancer Letters",

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TY - JOUR

T1 - Cancer related inflammation

T2 - The macrophage connection

AU - Sica, Antonio

AU - Allavena, Paola

AU - Mantovani, Alberto

N1 - Funding Information: This work was supported by Associazione Italiana Ricerca sul Cancro (AIRC), Italy; European Community and Ministero Istruzione Università Ricerca (MIUR), Italy; Istituto Superiore Sanita’ (ISS).

PY - 2008/8/28

Y1 - 2008/8/28

N2 - Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

AB - Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

KW - Angiogenesis

KW - Cancer

KW - Chemokines

KW - Cytokines

KW - Inflammation

KW - Macrophage polarization

KW - Therapeutic targets

KW - Tumor promotion

KW - Tumor-associated macrophages

UR - http://www.scopus.com/inward/record.url?scp=47749155653&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2008.03.028

DO - 10.1016/j.canlet.2008.03.028

M3 - Review article

SN - 0304-3835

VL - 267

SP - 204

EP - 215

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Cancer related inflammation: The macrophage connection

Abstract

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