TY - GEN
T1 - Cancer immunoprevention
T2 - 6th International Conference on Intelligent Computing, ICIC 2010
AU - Pappalardo, Francesco
AU - Pennisi, Marzio
AU - Cincotti, Alessandro
AU - Chiacchio, Ferdinando
AU - Motta, Santo
AU - Lollini, Pier Luigi
PY - 2010
Y1 - 2010
N2 - We present our experience of the artificial immunity induced by an immuoprevention vaccine succesfully tested on transgenic mice. The model mimics the phenomenon of initial cancer growing starting from the stage of the atypical hyperplasia and reproduces the action of the vaccine in activating the immune response. The model has been validated against in-vivo experiments. Finally we use the model to determine an optimal vaccination scheduling which reduce to a minimum the number of vaccine administrations still preventing the solid tumor formation is a population of virtual mice. The vaccination schedule proposed by the model is substantially lighter than the one's determined by the standard intuitive procedure.
AB - We present our experience of the artificial immunity induced by an immuoprevention vaccine succesfully tested on transgenic mice. The model mimics the phenomenon of initial cancer growing starting from the stage of the atypical hyperplasia and reproduces the action of the vaccine in activating the immune response. The model has been validated against in-vivo experiments. Finally we use the model to determine an optimal vaccination scheduling which reduce to a minimum the number of vaccine administrations still preventing the solid tumor formation is a population of virtual mice. The vaccination schedule proposed by the model is substantially lighter than the one's determined by the standard intuitive procedure.
KW - Artificial immunity
KW - agent based models
KW - cancer
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=77957010572&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-14831-6_15
DO - 10.1007/978-3-642-14831-6_15
M3 - Conference contribution
AN - SCOPUS:77957010572
SN - 3642148301
SN - 9783642148309
T3 - Communications in Computer and Information Science
SP - 111
EP - 118
BT - Advanced Intelligent Computing Theories and Applications - 6th International Conference on Intelligent Computing, ICIC 2010, Proceedings
Y2 - 18 August 2010 through 21 August 2010
ER -