TY - JOUR
T1 - Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration
AU - Zaninetti, R.
AU - Tacchi, S.
AU - Erriquez, J.
AU - Distasi, C.
AU - Maggi, R.
AU - Cariboni, A.
AU - Condorelli, F.
AU - Canonico, P. L.
AU - Genazzani, Armando A.
PY - 2008/3
Y1 - 2008/3
N2 - During development, many neurons display calcium-dependent migration, but the role of this messenger in regulating gene expression leading to this event has not yet been elucidated. Among the decoders of calcium signals is calcineurin, a Ca2+/calmodulin serine/threonine phosphatase that has been involved in both short-term and long-term cellular changes. By using immortalized GnRH-secreting neurons, we now show that, in vitro, Ca 2+-dependent gene expression, proceeding via calcineurin and the transcription factor nuclear factor of activated T cells, is a key player controlling the chemomigratory potential of developing GnRH-secreting neurons. Furthermore, our data highlight the switch nature of this phosphatase, whose activation or inactivation guides cells to proceed from one genetic program to the next.
AB - During development, many neurons display calcium-dependent migration, but the role of this messenger in regulating gene expression leading to this event has not yet been elucidated. Among the decoders of calcium signals is calcineurin, a Ca2+/calmodulin serine/threonine phosphatase that has been involved in both short-term and long-term cellular changes. By using immortalized GnRH-secreting neurons, we now show that, in vitro, Ca 2+-dependent gene expression, proceeding via calcineurin and the transcription factor nuclear factor of activated T cells, is a key player controlling the chemomigratory potential of developing GnRH-secreting neurons. Furthermore, our data highlight the switch nature of this phosphatase, whose activation or inactivation guides cells to proceed from one genetic program to the next.
UR - http://www.scopus.com/inward/record.url?scp=40849118395&partnerID=8YFLogxK
U2 - 10.1210/me.2007-0277
DO - 10.1210/me.2007-0277
M3 - Article
SN - 0888-8809
VL - 22
SP - 729
EP - 736
JO - Molecular Endocrinology
JF - Molecular Endocrinology
IS - 3
ER -